Fig. 3

Box showing illustrative data of increased occurrence of secondary infections in our institution. All patients with a CAPA had a pulmonary infiltrate on conventional X-ray or chest CT, clinical deterioration and a positive VIRCLIA^® Aspergillus chemiluminescent immunoassay on bronchoalveolar lavage fluid, in accordance with the CAPA definition. HSV pneumonitis was diagnosed if there were a positive HSV PCR in BALF, a positive PCR in plasma and a cytological HSV staining in BALF in combination with respiratory deterioration with pulmonary infiltrate on conventional X-ray or chest CT