Table 1 Demographic and clinical characteristics of purpura fulminans (PF) in children at admission, and intra-hospital outcomes, N = 1042
Total | |
|---|---|
Number of cases (%) | 1042 |
Age (years), mean ± SD | 4.2 ± 4.2 |
Median (n = 1042) | 2.5 |
Sex (male) (n = 989) | 585 (59.1) |
Daycare modality (n = 852) | |
Home | 372 (43.7) |
Daycare centre | 422 (49.5) |
Child minder | 58 (6.8) |
Underlying conditions (n = 1042) | 95 (9.1) |
Prematurity (%)* (n = 587) | 72 (6.9) |
Cardiopathy (n = 846) | 6 (0.7) |
Acquired immunodeficiency (n = 838) | 4 (0.5) |
Congenital immunodeficiency (n = 974) | 4 (0.4) |
Recurrent meningitis (n = 960) | 5 (0.5) |
Asplenia (n = 919) | 2 (0.2) |
Cochlear implants (n = 712) | 2 (0.3) |
Initial antibiotic therapy by 3GC | 1042 (100) |
Antibiotic treatment within the 24 h before admission (%)* (n = 933) | 425 (45.6) |
Clinical characteristics | |
Seizure before antibiotic therapy (%)* (n = 976) | 78 (8) |
Seizure after antibiotic therapy (%)* (n = 957) | 58 (6.1) |
Coma (%)* (n = 955) | 294 (30.8) |
Mechanical ventilation (%)* (n = 975) | 433 (44.4) |
Shock (%)* (n = 1002) | 766 (76.5) |
Complications (%)* (n = 1042) | 143 (13.7)** |
Neurological | 32 (3.1) |
Non-neurological (including imputations) | 114 (10.9) |
Limb amputation | 20 (1.9) |
Death (%) (n = 1032) | 166 (16.1) |
Time from admission to death (days), mean ± SD* | 3.9 ± 11.3 |
Median | 1 |