Effects of early extubation followed by noninvasive ventilation versus standard extubation on the duration of invasive mechanical ventilation in hypoxemic non-hypercapnic patients: a systematic review and individual patient data meta-analysis of randomized controlled trials

Table 3 Results from 1-stage IPD-MA, according to different models

	Mean i-MV time (days)	Mean total ventilation time (days)	VAP (odds ratio)	Time to ICU discharge (time ratio)	Time to ICU death (time ratio)	Time to hospital discharge (time ratio)
Model 1^*	− 3.26 (− 5.01 to − 1.50)	− 1.86 (− 3.65 to − 0.06)	0.23 (0.08 to 0.68)	0.82 (0.70 to 0.98)	0.77 (0.49 to 1.22)	0.80 (0.69 to 0.94)
	p < 0.001	p = 0.042	p = 0.008	p = 0.027	p = 0.273	p = 0.006
Model 2^†	− 3.43 (− 5.19 to − 1.68)	− 2.04 (− 3.84 to − 0.25)	0.25 (0.08 to 0.75)	0.81 (0.69 to 0.96)	0.68 (0.41 to 1.15)	0.81 (0.69 to 0.95)
	p < 0.001	p = 0.025	p = 0.014	p = 0.015	p = 0.152	p = 0.010
Model 3^‡	− 3.43 (− 5.17 to − 1.69)	− 2.04 (− 3.82 to − 0.27)	0.24 (0.08 to 0.71)	0.81 (0.68 to 0.96)	0.75 (0.45 to 1.23)	0.81 (0.69 to 0.95)
	p < 0.001	p = 0.024	p = 0.014	p = 0.015	p = 0.251	p = 0.011

*Model 1: adjusted by study (fixed-effect model)
^†Model 2: adjusted by study, age, gender, PaO₂/FiO₂, risk score (fixed-effect model)
^‡Model 3: adjusted by study, age, gender, PaO₂/FiO₂, risk score (random effect model)
ICU Intensive Care Unit, IPD-MA Individual Patient Data Meta-Analysis, i-MV invasive Mechanical Ventilation, PaO₂/FiO₂ arterial partial pressure of oxygen and oxygen inspired fraction ratio, VAP Ventilator Associated Pneumonia

ISSN: 1364-8535