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Table 3 Results from 1-stage IPD-MA, according to different models

From: Effects of early extubation followed by noninvasive ventilation versus standard extubation on the duration of invasive mechanical ventilation in hypoxemic non-hypercapnic patients: a systematic review and individual patient data meta-analysis of randomized controlled trials

  Mean i-MV time (days) Mean total ventilation time (days) VAP (odds ratio) Time to ICU discharge (time ratio) Time to ICU death (time ratio) Time to hospital discharge (time ratio)
Model 1* − 3.26 (− 5.01 to − 1.50) − 1.86 (− 3.65 to − 0.06) 0.23 (0.08 to 0.68) 0.82 (0.70 to 0.98) 0.77 (0.49 to 1.22) 0.80 (0.69 to 0.94)
  p < 0.001 p = 0.042 p = 0.008 p = 0.027 p = 0.273 p = 0.006
Model 2 − 3.43 (− 5.19 to − 1.68) − 2.04 (− 3.84 to − 0.25) 0.25 (0.08 to 0.75) 0.81 (0.69 to 0.96) 0.68 (0.41 to 1.15) 0.81 (0.69 to 0.95)
  p < 0.001 p = 0.025 p = 0.014 p = 0.015 p = 0.152 p = 0.010
Model 3 − 3.43 (− 5.17 to − 1.69) − 2.04 (− 3.82 to − 0.27) 0.24 (0.08 to 0.71) 0.81 (0.68 to 0.96) 0.75 (0.45 to 1.23) 0.81 (0.69 to 0.95)
  p < 0.001 p = 0.024 p = 0.014 p = 0.015 p = 0.251 p = 0.011
  1. *Model 1: adjusted by study (fixed-effect model)
  2. Model 2: adjusted by study, age, gender, PaO2/FiO2, risk score (fixed-effect model)
  3. Model 3: adjusted by study, age, gender, PaO2/FiO2, risk score (random effect model)
  4. ICU Intensive Care Unit, IPD-MA Individual Patient Data Meta-Analysis, i-MV invasive Mechanical Ventilation, PaO2/FiO2 arterial partial pressure of oxygen and oxygen inspired fraction ratio, VAP Ventilator Associated Pneumonia