Skip to main content

Table 2 Patient characteristics at ICU admission and ventilator settings and gas exchange at randomization

From: Effects of early extubation followed by noninvasive ventilation versus standard extubation on the duration of invasive mechanical ventilation in hypoxemic non-hypercapnic patients: a systematic review and individual patient data meta-analysis of randomized controlled trials

  Control (n = 226) Intervention (n = 233) p value
Characteristics at ICU admission
Age, mean (SD) 60 (16) 63 (15) 0.037
Male, n (%) 134 (59%) 135 (58%) 0.769
SAPS II at ICU entry, mean (SD) 44 (15)* 45 (17) 0.698
APACHE II at ICU entry, mean (SD) 19 (7) 19 (7)§ 0.995
Type of patient (medical vs. surgical) 116/110 140/93 0.059
Main causes of i-MV, n (%)    0.076
ARDS 64 (28%) 57 (25%)  
Pneumonia 19 (8%) 22 (9%)  
Septic Shock 13 (6%) 10 (4%)  
Polytrauma 23 (10%) 28 (12%)  
Post-operative ARF 69 (31%) 51(21%)  
Gastrointestinal Bleeding 7 (3%) 13 (6%)  
Cerebral Bleeding 4 (2%) 2 (1%)  
Pancreatitis 4 (2%) 4 (2%)  
Others 23 (10%) 46 (20%)  
Ventilator settings and gas exchange at randomization
PEEP (cmH2O), mean (SD) 7 (2)° 7 (2)°° 0.451
Pressure Support (cmH2O)§, mean (SD) 11 (5) 11 (4)”” 0.414
FiO2 (%), mean (SD) 36 (8) 37 (8) 0.124
PaO2 (cmH2O), mean (SD) 91 (22)** 89 (21)++ 0.287
PaO2/FiO2 (mmHg), mean (SD) 258 (77)** 242 (58)++ 0.014
pH, mean (SD) 7.43 (0.06)^ 7.44 (0.05) ++ 0.748
PaCO2 (mmHg), mean (SD) 39 (7)** 39 (6)++ 0.741
  1. APACHE II Acute Physiology and Chronic Health Disease Classification System II, ARDS Acute Respiratory Distress Syndrome, ARF Acute Respiratory Failure, BMI Body Mass Index, FiO2 inspired fraction of oxygen, ICU Intensive Care Unit, PaCO2 carbon dioxide arterial partial pressure, PaO2 oxygen arterial partial pressure, PaO2/FiO2 oxygen arterial partial pressure and oxygen inspired fraction ratio, PEEP Positive End-Expiratory Pressure, SAPS II Simplified Acute Physiology Score II, i-MV invasive Mechanical Ventilation, SD Standard Deviation, n number, vs. versus
  2. *n = 63, n = 65, n = 154, §n = 162, **n = 225, ++n = 232, ^n = 226, °n = 224, °°n = 229, n = 209, “” n = 217