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Table 2 Patient characteristics at ICU admission and ventilator settings and gas exchange at randomization

From: Effects of early extubation followed by noninvasive ventilation versus standard extubation on the duration of invasive mechanical ventilation in hypoxemic non-hypercapnic patients: a systematic review and individual patient data meta-analysis of randomized controlled trials

 

Control (n = 226)

Intervention (n = 233)

p value

Characteristics at ICU admission

Age, mean (SD)

60 (16)

63 (15)

0.037

Male, n (%)

134 (59%)

135 (58%)

0.769

SAPS II at ICU entry, mean (SD)

44 (15)*

45 (17)

0.698

APACHE II at ICU entry, mean (SD)

19 (7)

19 (7)§

0.995

Type of patient (medical vs. surgical)

116/110

140/93

0.059

Main causes of i-MV, n (%)

  

0.076

ARDS

64 (28%)

57 (25%)

 

Pneumonia

19 (8%)

22 (9%)

 

Septic Shock

13 (6%)

10 (4%)

 

Polytrauma

23 (10%)

28 (12%)

 

Post-operative ARF

69 (31%)

51(21%)

 

Gastrointestinal Bleeding

7 (3%)

13 (6%)

 

Cerebral Bleeding

4 (2%)

2 (1%)

 

Pancreatitis

4 (2%)

4 (2%)

 

Others

23 (10%)

46 (20%)

 

Ventilator settings and gas exchange at randomization

PEEP (cmH2O), mean (SD)

7 (2)°

7 (2)°°

0.451

Pressure Support (cmH2O)§, mean (SD)

11 (5)

11 (4)””

0.414

FiO2 (%), mean (SD)

36 (8)

37 (8)

0.124

PaO2 (cmH2O), mean (SD)

91 (22)**

89 (21)++

0.287

PaO2/FiO2 (mmHg), mean (SD)

258 (77)**

242 (58)++

0.014

pH, mean (SD)

7.43 (0.06)^

7.44 (0.05) ++

0.748

PaCO2 (mmHg), mean (SD)

39 (7)**

39 (6)++

0.741

  1. APACHE II Acute Physiology and Chronic Health Disease Classification System II, ARDS Acute Respiratory Distress Syndrome, ARF Acute Respiratory Failure, BMI Body Mass Index, FiO2 inspired fraction of oxygen, ICU Intensive Care Unit, PaCO2 carbon dioxide arterial partial pressure, PaO2 oxygen arterial partial pressure, PaO2/FiO2 oxygen arterial partial pressure and oxygen inspired fraction ratio, PEEP Positive End-Expiratory Pressure, SAPS II Simplified Acute Physiology Score II, i-MV invasive Mechanical Ventilation, SD Standard Deviation, n number, vs. versus
  2. *n = 63, n = 65, n = 154, §n = 162, **n = 225, ++n = 232, ^n = 226, °n = 224, °°n = 229, n = 209, “” n = 217