Control (n = 226) | Intervention (n = 233) | p value | |
---|---|---|---|
Characteristics at ICU admission | |||
Age, mean (SD) | 60 (16) | 63 (15) | 0.037 |
Male, n (%) | 134 (59%) | 135 (58%) | 0.769 |
SAPS II at ICU entry, mean (SD) | 44 (15)* | 45 (17)† | 0.698 |
APACHE II at ICU entry, mean (SD) | 19 (7)‡ | 19 (7)§ | 0.995 |
Type of patient (medical vs. surgical) | 116/110 | 140/93 | 0.059 |
Main causes of i-MV, n (%) | 0.076 | ||
ARDS | 64 (28%) | 57 (25%) | |
Pneumonia | 19 (8%) | 22 (9%) | |
Septic Shock | 13 (6%) | 10 (4%) | |
Polytrauma | 23 (10%) | 28 (12%) | |
Post-operative ARF | 69 (31%) | 51(21%) | |
Gastrointestinal Bleeding | 7 (3%) | 13 (6%) | |
Cerebral Bleeding | 4 (2%) | 2 (1%) | |
Pancreatitis | 4 (2%) | 4 (2%) | |
Others | 23 (10%) | 46 (20%) | |
Ventilator settings and gas exchange at randomization | |||
PEEP (cmH2O), mean (SD) | 7 (2)° | 7 (2)°° | 0.451 |
Pressure Support (cmH2O)§, mean (SD) | 11 (5)” | 11 (4)”” | 0.414 |
FiO2 (%), mean (SD) | 36 (8) | 37 (8) | 0.124 |
PaO2 (cmH2O), mean (SD) | 91 (22)** | 89 (21)++ | 0.287 |
PaO2/FiO2 (mmHg), mean (SD) | 258 (77)** | 242 (58)++ | 0.014 |
pH, mean (SD) | 7.43 (0.06)^ | 7.44 (0.05) ++ | 0.748 |
PaCO2 (mmHg), mean (SD) | 39 (7)** | 39 (6)++ | 0.741 |