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Table 1 Comparison of demographic characteristics of COVID-19 and non-COVID-19 acute respiratory distress syndrome

From: COVID-19 ARDS is characterized by higher extravascular lung water than non-COVID-19 ARDS: the PiCCOVID study

Variables

COVID-19 (N = 60)

Non-COVID-19 (N = 60)

p value

Age (years)

64 (54–72)

62 (55–73)

0.967

Male (n)

46 (77)

34 (57)

0.033

BMI (kg/m2)

29.2 (26.3–33.2)

26.0 (21.8–32.0)

0.010

SAPS II score

40 (32–49)

55 (46–66)

 < 0.001

SOFA total

6 (3–9)

9 (7–11)

0.001

SOFA respiration

2 (2–3)

3 (3–4)

0.015

SOFA hepatic

0 (0–0)

0 (0–1)

0.030

SOFA cardiovascular

2 (0–4)

4 (0–4)

0.036

SOFA coagulation

0 (0–1)

0 (0–1)

0.673

SOFA central nervous system

0 (0–0)

0 (0–1)

0.002

SOFA renal

0 (0–2)

1 (0–2)

0.094

Medical history

   

Hypertension (n)

29 (48)

24 (40)

0.462

Diabetes mellitus (n)

24 (40)

16 (27)

0.175

COPD/asthma (n)

8 (13)

6 (10)

0.776

Chronic kidney disease (n)

10 (17)

7 (12)

0.601

Immunodepression (n)

13 (22)

31 (52)

0.001

Smoking (n)

8 (13)

25 (42)

0.001

Alcohol abuse (n)

6 (10)

19 (32)

0.007

Adjunctive therapies

   

Prone position (n)

50 (83)

39 (65)

0.037

Sessions (n)

4 (1–7)

1 (0–2)

 < 0.001

NMBA (n)

45 (75)

43 (72)

0.837

Corticosteroids for septic shock* (n)

11 (18)

47 (78)

 < 0.001

Corticosteroids for COVID-19**

18 (30)

0 (0)

 < 0.001

Time between corticoids start and first thermodilution

2 (1–4)***

1 (1–3.5)****

0.628

Inhaled nitric oxide (n)

6 (10)

4 (7)

0.741

ECMO (n)

17 (28)

7 (12)

0.040

Renal replacement therapy (n)

13 (22)

26 (43)

0.019

HFNC (n)

31 (52)

14 (23)

0.003

Duration of HFNC before MV (days)

3 (2–4)

1.5 (1–2)

0.032

NIV (n)

3 (5)

7 (12)

0.322

Duration of NIV before MV (days)

1(-)

1 (0.6–2.5)

0.555

Time from MV to TPTD (days)

1 (0–1)

0 (0–1)

0.008

ICU length of stay (days)

15 (8–24)

17 (9–26)

0.440

Duration of MV (days)

13 (6–22)

15 (6–23)

0.532

MV free days (days)

0 (0–3)

0 (0–8)

0.386

  1. Bold font indicates statistical significance
  2. Values are expressed as median (interquartile range) or n (%)
  3. ARDS acute respiratory distress syndrome, BMI body mass index, COPD chronic obstructive pulmonary disease, ECMO extracorporeal membrane oxygenation, HFNC high-flow nasal canula, ICU intensive care unit, MV mechanical ventilation, NIV noninvasive ventilation, NMBA neuromuscular blocking agent, SAPS simplified acute physiologic score, SOFA Sequential Organ Failure Assessment, TPTD transpulmonary thermodilution
  4. * Hydrocortisone 200 mg/d; ** dexamethasone 6 mg/d, equivalent to hydrocortisone 160 mg/d; *** reported for the 18 patients who received corticosteroids before the set-up of the thermodilution device. **** reported for the 4 patients who received corticosteroids before the set-up of the thermodilution device
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Critical Care

ISSN: 1364-8535