Table 1 Characteristics of each study
Authors | Country | Sample size | Setting | Study period | Definition of ARDS | Definition of RV injury | Mortality |
|---|---|---|---|---|---|---|---|
Osman /2009 | France | 145 | Multi-center, post-hoc analysis of RCT | January 1999–June 2001 | American-European consensus conference | (1) MPAP > 25 mmHg, (2) CVP > PAOP, and (3) SVI < 30 mL/m2, based on PAC | 28-day |
Bull/2010 | United States | 367 | Post-hoc analysis of multicenter randomized controlled trial | June 2000–Oct 2005 | American-European consensus conference | CVP > PAOP | 60-day |
Fichet/2012 | France | 50 | Single-center, prospective | Not reported | American-European consensus conference | TAPSE < 12 mm or St < 11.5 cm/sec | ICU |
Legras/2015 | France | 166 | Multi-center, prospective | November 2009-June 2012 | American-European consensus conference | RVEDA/LVEDA ratio > 0.6 associated with systolic paradoxical ventricular septal motion by TTE or TEE | 28-day |
Lazzeri/2016 | Italy | 74 | Single-center, retrospective | October 2009–December 2013 | Berlin definition. All included patients underwent VV-ECMO | RVEDA/LVEDA ratio > 0.6 by TTE or TEE | ICU |
Mekonstso Dessap/2016 | France | 752 | Multi-center, prospective | 1994–2012 | Berlin definition (Although the study was initiated begore 2011, all met the Berlin definition.) | RVEDA/LVEDA ratio > 0.6 associated with septal dyskinesia by TEE | In-hospital |
See/2017 | Singapore | 234 | Single-center, prospective | September 2012–May 2014 | Berlin definition | RVEDA/LVEDA ratio ≥ 1 by TTE | In-hospital |
Bonizzoli/2018 | Italy | 28 | Single-center, retrospective | January 2016–June 2017 | Berlin definition | RV free wall strain < 20% | ICU |
Zeiton/2018 | Egypt | 45 | Single-center, prospective | June 2016–December 2016 | Berlin definition | RVEDA/LVEDA ratio > 0.6 associated with septal dyskinesia by TTE | 28-day |