Drug | ECTR | T1/2 (Hours) | Clearance (mL/min) | References | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
During ECTR | Endogenous | ECTR | Endogenous | |||||||||
Median | n | Range | Normal GFR | ESKD | Median | n | Range | Normal GFR | ESKD | |||
Acebutolol | HD | 6.1 (Met = 7.2) | 7 | 2.2–7 | 4–10 | 45 (Met = 33.6) | 12 | 30.5–55.1 | 600–800 | N/A | ||
HF-HP | 0.3 | 1 | Â | 151 | 1 | Â | ||||||
Atenolol | HD | 4.6 | 48 | 0.5–17.8 | 5–8 | 50–100 | 119.5 | 25 | 18–311 | 140–180 | 20 | [73, 76, 78, 79, 85, 90, 91, 100, 101, 105, 118, 123, 124, 128] |
CKRT | 22 | 2 | 14.5–29.5 | 47 | 3 | 19.9–48 | ||||||
HD-HP | 3.4 | 1 | Â | N/A | ||||||||
PD | 23 | 17 | 19.2–34 | 2.6 | 7 | 1.3–3.7 | ||||||
Betaxolol | HD | N/A | 14–16 | 25–35 | 17.5 ± 0.7 | 12 |  | 220–270 | 100–150 | [86] | ||
PD | N/A | 11.7 ± 1.2 | 12 |  | ||||||||
Bisoprolol | HD | 7.8 | 16 | 6.4–9.6 | 9–12 | 25–35 | 41.8 | 16 | 30.5–70 | 200–250 | 50 | |
PD | 23.6 | 3 | 20.8–26.4 | N/A | ||||||||
Carvedilol | HD | 4.6 | 8 | 4.1–5.3 | 6–7 | 12.1 | 14 | 12.1–38.6 | 600 | |||
Esmolol | HD | 0.12 ± 0.1 | 6 |  | 0.2 | Met = 76.8 ± 39.1 | 6 |  | 10,000–15,000 | [95] | ||
PD | 0.13 ± 0.1 | 6 |  | Met = 2.7 ± 0.5 | 6 |  | ||||||
Labetalol | HD | 1.8 | 7 | 0.6–3.8 | 3–10 | 10–12 | 37.4 | 14 | 25.7–97 | 1200–2000 | ||
PD | 13.1 ± 6.3 | 8 |  | 1.9 ± 1.7 | 8 |  | ||||||
Mepindolol | HD | 3.0 | 2 |  | 3–6 | 31 | 2 |  | 650 | N/A | [88] | |
Metipranolol | HD | 1.4 ± 0.5 | 8 |  | 2.5–3.0 | N/A | 1100–1300 | N/A | [97] | |||
Metoprolol | HD | 2.9 (Met = 5) | 8 | 2.3–3 | 3–5 | 101 | 8 |  | 800–1200 | |||
HP | 2.2 | 1 | Â | 96.1 | 1 | Â | ||||||
Nadolol | HD | 3.5 | 6 | 3.0–8.5 | 10–15 | 30–45 | 82 | 15 | 46.4–102 | 120–250 | 30 | |
Oxprenolol | HD | Met = 5.6 | 3 |  | 1–2 | N/A | 600–750 | 550 | [84] | |||
Practolol | HD | 14 (Met = 5) | 14 | 8–30 | 10–13 | 60–80 |  > 100* | 6 |  | 135 | 20 | |
Propranolol | HP | 5.6 | 3 | 4.9–8.9 | 3–5 | 189 | 2 | 188–191 | 800–1200 | |||
HD | 3.4 | 23 | 1.5–8 | 9.4 | 11 | 3.8–26.5 | ||||||
TPE | 1.2 | 1 | Â | N/A | ||||||||
Sotalol | HD | 7 | 9 | 3.5–9.5 | 5–9 | 35–60 | 80 | 3 | 67–80 | 120–160 | 20–25 | |
HP-HD | 2.8 | 1 | Â | N/A | ||||||||
CKRT | 18 | 1 | Â | 53.1 | 1 | Â | ||||||
Talinolol | HD | N/A | 10–12 | 20–25 | 28 | 7 |  | 320–380 | ||||
HP | 3.3 | 2 | 2.7–3.8 | 109 | 2 | 96–121 | ||||||
Timolol | HD | 3.8 | 2 | 2.3–5.2 | 3–5 | N/A | 450–580 | N/A | [72] |