Table 1 Demographic and clinical characteristics at initiation of awake ECMO support
From: Extracorporeal membrane oxygenation in non-intubated immunocompromised patients
Characteristic at inclusion | Median (IQR)/no (%) |
|---|---|
Number of patients | 18 |
Age—years | 54 (36–60) |
Sex—no (%) | |
Male | 11 (61.1) |
Female | 7 (38.9) |
BMI—kg/m2 | 24.5 (21.3–27.1) |
Adipositas (BMI > 30 kg/m2)—no (%) | 2 (11.1) |
Cause of immunosupression—no (%) | |
Solid organ transplant | 7 (38.9) |
HSCT | 6 (33.3) |
AIDS | 2 (11.1) |
Rheumatological disease | 3 (16.7) |
Pathogen—no (%) | |
Gram + | 2 (11.1) |
Gram− | 3 (16.7) |
CMV | 1 (5.6) |
Fungal | 2 (11.1) |
PcP | 8 (44.4) |
Non-identified | 5 (27.8) |
Comorbidities—no (%) | |
COPD | 3 (16.7) |
Cystic fibrosis | 1 (5.6) |
Pulmonary fibrosis | 6 (33.3) |
Pulmonary hypertension | 1 (5.6) |
Arterial hypertension | 5 (27.8) |
Congestive heart failure | 1 (5.6) |
Diabetes mellitus | 3 (16.7) |
Chronic kidney disease | 5 (27.8) |
Ventilation support—no (%) | |
HFNC | 1 (5.6) |
NIV | 17 (94.4) |
Respiratory parameters | |
FiO2 | 1 (1–1) |
PEEP—cmH2O | 7 (5–8) |
Breaths per minute | 32 (29–38) |
Tidal volume—ml | 593 (476–786) |
Minute ventilation—l/min | 21.3 (13.8–24.4) |
Peak—cmH2O | 17 (14–19) |
PaO2—mmHg | 65 (58–82) |
PaO2/FiO2—mmHg | 72 (65–82) |
PaCO2—mmHg | 40 (35–59) |
pH | 7.36 (7.3–7.44) |
Lactate—mmol/l | 1.5 (1.2–1.9) |
Vasopressor—no (%) | 5 (27.8) |
Norepinephrine dose—μg/kg/min | 0 (0–0.068) |
Inotropic—no (%) | 0 (0) |
Renal replacement therapy—no (%) | 1 (5.6) |
SOFA-score (points) | 7 (4–8) |
Organ dysfunction—no (%) | |
Respiratory (PaO2/FiO2 < 300) | 18 (100) |
Coagulation (thrombocytes < 100) | 5 (27.8) |
Liver (bilirubin > 33 μmol/l) | 2 (11.1) |
Cardiovascular (dobutamine or noradrenaline) | 5 (27.8) |
Neurological (GCS < 13) | 0 (0) |
Renal (creatinine > 170 μmol/l) | 3 (16.7) |
Multi-organ dysfunction—no (%) | |
Two | 11 (61.1) |
Three | 1 (5.6) |
Four | 1 (5.6) |
Five | 0 (0) |
Six | 0 (0) |
CRP—mg/l | 173 (78–226) |
PCT—μg/l | 0.8 (0.3–1.5) |
Creatinine—μmol/l | 69 (53–107) |
24 h diuresis—ml | 1230 (360–2165) |
ECMO settings (directly after cannulation) | |
Veno-venous | 18 (100) |
Cannulation (inflow–outflow) | |
Femoral-jugular | 16 (88.8) |
Femoral–femoral | 1 (5.6) |
Femoral-subclavia | 1 (5.6) |
Pump speed—rpm | 3410 (3030–3671) |
Blood flow—l/min | 3.6 (3.3–4) |
FiO2 | 100 (100–100) |
Sweep gas flow—l/min | 3.5 (2–4.1) |