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Table 2 Characteristics and disease progression in patients requiring invasive mechanical ventilation

From: Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort

 

Overall N = 234

Standard oxygen therapy N = 54

High-flow oxygen therapy N = 45

Non-invasive positive-pressure ventilation N = 43

Invasive mechanical ventilation N = 92

P value

Time from hospital admission to intubation, days

2 [1, 5]

3 [1, 5]

3 [2, 6]

4 [3, 7]

1 [0, 3]

<0.001

Duration of noninvasive respiratory support, days

1 [1, 2]

1 [1, 1]

1 [1, 2]

1 [1, 2]

0 [0, 0]

0.109

SOFA score on intubation day

6 [5, 8]

6 [6, 8]

7 [6, 8]

6 [5, 7]

7 [6, 8]

0.258

Ventilatory parameters after intubation

FiO2, %

60 [44, 75]

50 [40, 67]

60 [44, 67]

45 [41, 65]

63 [45, 80]

0.022

SpO2, %

94 [90, 97]

91 [88, 95]

94 [91, 96]

93 [89, 96]

96 [92, 97]

0.082

PaO2/FiO2, mmHg

137 [95, 179]

143 [94, 195]

136 [99, 181]

146 [108, 169]

123 [90, 165]

0.256

PaCO2, kPa

5.5 [4.7, 6.4]

5.8 [5.1, 6.7]

5.8 [4.7, 6.6]

5.7 [4.9, 6.4]

5.1 [4.3, 5.8]

0.002

Tidal volume/IBW, ml/kg

6.0 [5.6 , 7]

6.4 [5.7, 7.0]

6.0 [5.5, 6.7]

6.0 [5.6, 7.3]

6.1 [5.7, 7.1]

0.982

Respiratory rate, 1/min

24 [20, 28]

24 [20, 28]

21 [18, 27]

23 [20. 27]

24 [21, 30]

0.008

PEEP, cmH2O

12 [10, 12]

10 [10, 12]

10 [10, 12]

12 [10, 14]

12 [10, 14]

0.266

Plateau pressure, cmH2O

23 [21, 26]

24 [22, 25]

24 [22, 25]

24 [23, 27]

21 [21, 25]

0.838

Driving pressure, cmH2O

13 [10, 14]

13 [10, 14]

14 [12, 15]

13 [12, 14]

11 [10, 14]

0.96

Static compliance, ml/cmH2O

35 [26, 44]

34 [27, 44]

29 [25, 36]

28 [24, 34]

36 [31, 49]

0.603

Treatment

Corticosteroids

50 (21)

11 (20)

13 (29)

12 (28)

14 (15)

0.194

Organ failure and support during ICU stay

Prone positioning

148 (63)

35 (64)

31 (68)

27 (62)

55 (59)

0.764

Decrease in CRP from Day 0–7, %

27 [−77, 83]

19 [−100, 67]

17 [−27, 90]

21 [−103, 85]

42 [−48, 87]

0.02*

Vasopressors

187 (80)

45 (83)

38 (84)

39 (91)

65 (71)

0.029

Acute kidney injury

52 (22)

9 (17)

16 (36)

11 (26)

16 (17)

0.068

Renal replacement therapy

40 (17)

9 (17)

9 (20)

6 (14)

16 (17)

0.901

Tracheotomy

41 (17)

7 (13)

11 (24)

7 (16)

16 (17)

0.346

Outcome

Withdrawal of life supporting therapies

38 (17)

11 (20)

6 (13)

7 (17)

14 (17)

0.857

ICU length of stay, days

16 [9, 26]

13 [7, 21]

21 [13, 29]

18 [9, 27]

15 [9, 24]

0.052

ICU mortality

65 (28)

12 (21)

14 (31)

16 (37)

23 (25)

0.342

  1. Values are given as median [IQR] or count (percent) as appropriate
  2. ICU intensive care unit, SOFA Sequential Organ Failure Assessment, FiO2 fraction of inspired O2, SpO2 peripheral oxygen saturation, PaO2/FiO2 ratio partial pressure of arterial O2/fraction of inspired O2, PaCO2 partial pressure of arterial CO2, IBW ideal body weight, PEEP positive end expiratory pressure, CRP C-reactive protein
  3. *Calculated by means of mixed effect model analysis (Additional file 1: e-Table 2)