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Table 3 Center-adjusted receiver operating characteristic results reflecting the ability of pancreatic stone protein, C-reactive protein, procalcitonin, and their combinations to discriminate the presence and absence of sepsis

From: Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study

Parameter Accuracy Sensitivity Specificity LR− LR+
PSP 0.75 (0.67, 0.82) 0.74 (0.62, 0.86) 0.67 (0.60, 0.74) 0.40 (0.25, 0.63) 2.21 (1.70, 2.87)
CRP 0.77 (0.69, 0.84) 0.68 (0.55, 0.81) 0.77 (0.71, 0.83) 0.42 (0.28, 0.62) 2.91 (2.11, 4.02)
PCT 0.75 (0.68, 0.82) 0.72 (0.60, 0.84) 0.69 (0.62, 0.76) 0.41 (0.27, 0.64) 2.31 (1.75, 3.04)
PSP-CRP 0.79 (0.72, 0.86) 0.72 (0.60, 0.84) 0.73 (0.67, 0.80) 0.39 (0.25, 0.60) 2.69 (2.00, 3.61)
PSP-PCT 0.75 (0.68, 0.83) 0.76 (0.64, 0.87) 0.65 (0.58, 0.72) 0.38 (0.23, 0.61) 2.16 (1.68, 2.77)
CRP-PCT 0.77 (0.70, 0.84) 0.68 (0.55, 0.81) 0.77 (0.71, 0.83) 0.42 (0.28, 0.62) 2.91 (2.11, 4.02)
CRP-PCT-PSP 0.79 (0.72, 0.86) 0.72 (0.60, 0.84) 0.74 (0.68, 0.81) 0.38 (0.25, 0.59) 2.81 (2.08, 3.79)
  1. PSP pancreatic stone protein, CRP C-reactive protein, PCT procalcitonin, LR likelihood ratio