Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome

Table 2 Clinical characteristics of patients with COVID-19 with ARDS according to status at D28

	Survivors (n = 26)	Non-survivors (n = 14)	p value
Demographics
Age	65 [55–70]	67 [58–78]	0.3076
Gender	23 (88%)	13 (93%)	> 0.9999
Body mass index (kg/m²)	30 [27–35]	28 [24–30]	0.0960
Body mass index > 30 kg/m²	14 (54%)	3 (21%)	0.0921
Delay between first symptoms (Days)	7 [4–12]	5 [4–9]	0.1909
Comorbidities
Comorbidities			0.3202
0	15 (58%)	5 (36%)
≥ 1	11 (42%)	9 (64%)
Charlson score	0 [0–2]	2 [0–2]	0.1281
Severity scores
SOFA score	8 [3–10]	8 [4–8]	0.7937
SAPS II score	41 [31–52]	40 [33–59]	0.5893
PaO₂/FiO₂ at admission	150 [94–169]	116 [94–162]	0.2993
ARDS severity mild	1 (4%)	1 (7%)	> 0.9999
Moderate	18 (69%)	9 (64%)	> 0.9999
Severe	7 (27%)	4 (29%)	> 0.9999
Follow-up
Days in ICU	40 [16–76]	11 [6–20]	0.0008
Days in hospital	64 [38–77]	15 [7–20]	< 0.0001
Secondary infections	21 (81%)	9 (64%)	0.2777

The results are shown as medians and interquartile ranges [Q1–Q3] for continuous variables or numbers and percentage for categorical variables. COVID-19 patients with ARDS were separated in two groups based on status at D28 after admission. Sepsis-related organ failure assessment (SOFA) and simplified acute physiology score II (SAPS II) scores were calculated during the first 24 h after admission. Patients were classified in ARDS severity groups according to Berlin criteria. ICU: intensive care unit. Data were compared using nonparametric Mann–Whitney test for continuous variables or Fisher’s exact test for categorical variables
p values inferior to 0.05 are highlighted in bold

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