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Table 1 Clinical characteristics of critically ill patients with COVID-19 at ICU admission

From: Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome

 

All patients (n = 64)

ARDS (n = 40)

No ARDS (n = 24)

p value

Demographics

 Age

65 [52–72]

66 [57–72]

55 [43–72]

0.0738

 Gender

51 (80%)

36 (90%)

15 (63%)

0.0116

 Body mass index (kg/m2)

28 [26–32]

29 [26–34]

28 [25–30]

0.2124

 Body mass index > 30 kg/m2

23 (36%)

17 (43%)

6 (25%)

0.1874

Comorbidities

 Diabetes

16 (25%)

11 (25%)

5 (21%)

0.7693

 Comorbidities

0.2979

  0

36 (56%)

20 (50%)

16 (67%)

 

  ≥ 1

28 (44%)

20 (50%)

8 (33%)

 

 Charlson score

0 [0–2]

1 [0–2]

0 [0–1]

0.0002

Admission symptoms

 Delay between first symptoms (Days)

7 [4–11]

7 [4–10]

8.5 [7–11]

0.2055

 Fever

52 (81%)

34 (85%)

18 (75%)

0.3414

 Cough

42 (66%)

24 (60%)

18 (75%)

0.2814

 Dyspnea

40 (63%)

28 (70%)

12 (50%)

0.1208

 Diarrhea

18 (28%)

10 (25%)

8 (33%)

0.5691

 Diffuse pain

13 (20%)

7 (18%)

6 (25%)

0.5300

 Altered general status

44 (69%)

24 (60%)

20 (83%)

0.0584

 Other

28 (44%)

16 (40%)

12 (50%)

 

Severity scores

 SOFA score

4 [2–8]

8 [4–9]

2 [2, 3]

< 0.0001

 SAPS II score

34 [26–45]

40 [32–54]

27 [21–33]

< 0.0001

 PaO2/FiO2 at admission

145 [92–191]

132 [95–166]

230 [83–298]

0.0152

Antiviral therapy

 Hydroxychloroquine

35 (55%)

20 (50%)

15 (63%)

0.4381

 Lopinavir/ritonavir

5 (8%)

3 (8%)

2 (8%)

> 0.9999

 Lopinavir/ritonavir + interferonβ

5 (8%)

4 (10%)

1 (4%)

> 0.9999

 Remdesivir

1 (2%)

1 (3%)

0 (0%)

0.5238

Organ support

 Mechanical ventilation

63 (98%)

40 (100%)

23 (96%)

0.3750

 Noninvasive ventilation

23 (36%)

0 (0%)

23 (100%)

 < 0.0001

 Invasive ventilation

40 (63%)

40 (100%)

0 (0%)

 < 0.0001

 Vasoactive drugs

24 (38%)

24 (60%)

0 (0%)

 < 0.0001

 Renal replacement therapy

15 (23%)

15 (38%)

0 (0%)

0.0004

Follow-up

 Days in ICU

10 [4–30]

21 [11–58]

4 [2–7]

0.003

 Days in hospital

21 [11–56]

33 [19–71]

13 [8–21]

< 0.0001

 Hospital mortality

19 (30%)

19 (48%)

0 (0%)

< 0.0001

 Day-28 mortality

14 (22%)

14 (35%)

0 (0%)

< 0.0001

 Day-90 mortality

19 (30%)

19 (48%)

0 (0%)

< 0.0001

 Secondary infections

32 (50%)

30 (75%)

2 (8%)

< 0.0001

  1. The results are shown as medians and interquartile ranges [Q1–Q3] for continuous variables or numbers and percentage for categorical variables. Patients were separated into two groups based on presence of acute respiratory distress syndrome (ARDS) according to Berlin definition during the first 72 h after admission. Sepsis-related organ failure assessment (SOFA) and simplified acute physiology score II (SAPS II) scores were calculated during the first 24 h after intensive care unit (ICU) admission. Data were compared using nonparametric Mann–Whitney test for continuous variables or Fisher’s exact test for categorical variables
  2. p values inferior to 0.05 are highlighted in bold
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Critical Care

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