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Table 3 Patients' characteristics at admission in ICU and outcome divided by O2-Responders versus O2-Non-Responders

From: Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients

Variables Overall (n = 78) O2-non-responders (n = 17, 22%) O2-responders (n = 61, 78%) p value
Males, no. (%) 61 (78) 13 (77) 48 (79) 0.845
Age (years) 62 (51–68) 56 (51–66) 62 (52–68) 0.389
BMI (kg/m2) 27 (25–31) 26 (24–31) 27 (26–31) 0.670
SOFA score 4 (3–5) 4 (3–5) 4 (4, 5) 0.294
APACHE II score 10 (8–12) 11 (8–14) 10 (8–12) 0.620
Intubated, no. (%)a 75 (96) 16 (94) 59 (97) 0.622
Respiratory rate (breaths/min)b 20 (18–22) 19 (18–22) 20 (17–22) 0.813
FiO2 (%)b 75 (60–90) 80 (60–88) 70 (60–90) 0.839
PEEP (cmH2O)b 14 (12–15) 14 (11–14) 14 (12–15) 0.662
PaO2/FIO2 ratiob 111 (83–164) 99 (72–150) 114 (85–168) 0.419
ARDS severity, no. (%)b
 Mild 10 (13) 2 (13) 8 (14) 0.721
 Moderate 34 (45) 6 (38) 28 (48)  
 Severe 31 (41) 8 (50) 23 (39)  
Tidal volume/PBW (mL/kg)b 7.0 (6.4–7.8) 7.2 (6.2–7.9) 7.0 (6.4–7.8) 0.707
Plateau pressure (cmH2O)b 25 (22–27) 27 (24–28) 24 (22–27) 0.043
Driving pressure (cmH2O)b 12 (9–14) 14 (12–15) 12 (8–13) 0.022
Respiratory system compliance (mL/cmH2O)b 42 (32–53) 34 (30–45) 45 (34–56) 0.018
pH 7.36 (7.31–7.41) 7.33 (7.29–7.42) 7.37 (7.32–7.41) 0.244
PaO2 (mmHg) 78 (70–95) 76 (68–90) 80 (70–99) 0.443
PaCO2 (mmHg) 47 (40–56) 50 (39–58) 47 (41–55) 0.417
Ventilatory ratio 1.8 (1.4–2.0) 1.8 (1.4–2.5) 1.8 (1.4–2.0) 0.345
LDH (units/L) 414 (307–490) 418 (329–485) 400 (301–490) 0.620
ICU mortality, no. (%) 34 (44) 11 (65) 23 (38) 0.047
Hospital mortality, no. (%) 34 (44) 11 (65) 23 (38) 0.047
ICU LOS (days) 18 (11–34) 18 (12–47) 19 (11–33) 0.981
Hospital LOS (days) 36 (17–58) 32 (14–47) 39 (21–61) 0.295
Mechanical ventilation (days) 19 (11–35) 16 (11–35) 19 (11–35) 0.832
  1. Data are expressed either as median (interquartile range) or as frequency (percentage)
  2. BMI = Body Mass Index; SOFA = Sequential Organ Failure Assessment; APACHE II = Acute Physiologic Assessment and Chronic Health Evaluation II; FiO2 = Inspired fraction of oxygen; PEEP = Positive End-Expiratory Pressure; PBW: Predicted Body Weight; PaO2: partial pressure of oxygen in arterial blood; PaCO2: partial pressure of carbon dioxide in arterial blood; LDH: lactate dehydrogenase; LOS = Length of stay
  3. aPatients intubated same day of ICU admission
  4. bValues refer to patients intubated on the same day of ICU admission