Skip to main content

Table 3 Patients' characteristics at admission in ICU and outcome divided by O2-Responders versus O2-Non-Responders

From: Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients

Variables

Overall (n = 78)

O2-non-responders (n = 17, 22%)

O2-responders (n = 61, 78%)

p value

Males, no. (%)

61 (78)

13 (77)

48 (79)

0.845

Age (years)

62 (51–68)

56 (51–66)

62 (52–68)

0.389

BMI (kg/m2)

27 (25–31)

26 (24–31)

27 (26–31)

0.670

SOFA score

4 (3–5)

4 (3–5)

4 (4, 5)

0.294

APACHE II score

10 (8–12)

11 (8–14)

10 (8–12)

0.620

Intubated, no. (%)a

75 (96)

16 (94)

59 (97)

0.622

Respiratory rate (breaths/min)b

20 (18–22)

19 (18–22)

20 (17–22)

0.813

FiO2 (%)b

75 (60–90)

80 (60–88)

70 (60–90)

0.839

PEEP (cmH2O)b

14 (12–15)

14 (11–14)

14 (12–15)

0.662

PaO2/FIO2 ratiob

111 (83–164)

99 (72–150)

114 (85–168)

0.419

ARDS severity, no. (%)b

 Mild

10 (13)

2 (13)

8 (14)

0.721

 Moderate

34 (45)

6 (38)

28 (48)

 

 Severe

31 (41)

8 (50)

23 (39)

 

Tidal volume/PBW (mL/kg)b

7.0 (6.4–7.8)

7.2 (6.2–7.9)

7.0 (6.4–7.8)

0.707

Plateau pressure (cmH2O)b

25 (22–27)

27 (24–28)

24 (22–27)

0.043

Driving pressure (cmH2O)b

12 (9–14)

14 (12–15)

12 (8–13)

0.022

Respiratory system compliance (mL/cmH2O)b

42 (32–53)

34 (30–45)

45 (34–56)

0.018

pH

7.36 (7.31–7.41)

7.33 (7.29–7.42)

7.37 (7.32–7.41)

0.244

PaO2 (mmHg)

78 (70–95)

76 (68–90)

80 (70–99)

0.443

PaCO2 (mmHg)

47 (40–56)

50 (39–58)

47 (41–55)

0.417

Ventilatory ratio

1.8 (1.4–2.0)

1.8 (1.4–2.5)

1.8 (1.4–2.0)

0.345

LDH (units/L)

414 (307–490)

418 (329–485)

400 (301–490)

0.620

ICU mortality, no. (%)

34 (44)

11 (65)

23 (38)

0.047

Hospital mortality, no. (%)

34 (44)

11 (65)

23 (38)

0.047

ICU LOS (days)

18 (11–34)

18 (12–47)

19 (11–33)

0.981

Hospital LOS (days)

36 (17–58)

32 (14–47)

39 (21–61)

0.295

Mechanical ventilation (days)

19 (11–35)

16 (11–35)

19 (11–35)

0.832

  1. Data are expressed either as median (interquartile range) or as frequency (percentage)
  2. BMI = Body Mass Index; SOFA = Sequential Organ Failure Assessment; APACHE II = Acute Physiologic Assessment and Chronic Health Evaluation II; FiO2 = Inspired fraction of oxygen; PEEP = Positive End-Expiratory Pressure; PBW: Predicted Body Weight; PaO2: partial pressure of oxygen in arterial blood; PaCO2: partial pressure of carbon dioxide in arterial blood; LDH: lactate dehydrogenase; LOS = Length of stay
  3. aPatients intubated same day of ICU admission
  4. bValues refer to patients intubated on the same day of ICU admission