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Fig. 3 | Critical Care

Fig. 3

From: Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study

Fig. 3

Plasma biomarkers reveal distinct host response between critically ill patients with COVID-19 compared to critically ill controls. Volcano plot of 22 plasma biomarkers analyzed in blood collected within 24 h of ICU admission analyzed in COVID-19 (n = 78) relative to non-COVID-19 (n = 93) samples. Dashed line indicates Bonferroni-corrected threshold; dotted line indicates nominal 5% significance threshold. Blue dots represent biomarker concentrations that are lower in COVID-19 and gray represent concentrations higher in COVID-19. Estimates are adjusted for age, sex, BMI, and APACHE III score. Table provides plasma biomarkers, median (interquartile range), that significantly differed between ICU populations include angiopoietin-2:1 ratio (Ang-2:1 ratio), soluble receptor for advanced glycation end-products (sRAGE), soluble tumor necrosis factor receptor 1 (sTNFR-1), serum amyloid A (SAA) and angiopoietin-2 (Ang-2)

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Critical Care

ISSN: 1364-8535