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Table 3 Patients’ characteristics by tertiles of VE-cadherin on day 1

From: Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS

VE-cadherin (ng/mL) Lowest tertile
range: 528–1475
(125)
Middle tertile
range:1483–1985
(123)
Highest tertile
range:1988–7487
(127)
P*
SYN-1 (ng/mL)      
 Day 1 Median [IQR] 111 [77–262] 191 [87–384] 286 [140–655] 2.5 × 10–8
 Day 2 Median [IQR] 339 [200–723] 471 [252–820] 550 [287–1470] 4.1 × 10–5
 Day 7 Median [IQR] 408 [242–763] 459 [283–899] 555 [285–1270] 0.04
S1P (ng/mL)      
 Day 1 Median [IQR] 83 [63–116] 87.4 [63.7–119.2] 88.1 [64.0–121.6] 0.72
 Day 2 Median [IQR] 82 [62–120] 89.2 [68.0–118.9] 91.7 [74.0–130.5] 0.11
 Day 7 Median [IQR] 89 [62–119] 94.2 [72.5–136.2] 92.5 [71.0–139.2] 0.09
Sex      
 Female No. (%) 60 (48.0%) 57 (46.3%) 47 (37.0%) 0.17
Age (year) Mean ± SD 70.6 ± 12.5 69.1 ± 13.6 66.2 ± 14.9 0.05
BMI (kg/m2) Mean ± SD 26.9 ± 6.5 26.1 ± 4.9 27.0 ± 5.6 0.39
Mean arterial pressure (mmHg) Mean ± SD 72.9 ± 12.7 74.2 ± 12.6 71.8 ± 13.9 0.20
Heart rate (bpm) Mean ± SD 104 ± 21 106 ± 25 106 ± 19 0.76
Urine output (mL/h) Median[IQR] 65 [30–100] 60 [ 30–120] 50 [28–100] 0.55
Hemoglobin (g/dL) Mean ± SD 11.2 ± 1.8 10.9 ± 1.8 11.0 ± 1.6 0.55
PaO2/FiO2 Median[IQR] 203 [129–267] 200 [132–295] 201 [141–288] 0.71
Venous oxygen saturation (%) Mean ± SD 72.4 ± 9.7 74.5 ± 8.4 73.6 ± 9.9 0.24
Central venous pressure (mmHg) Mean ± SD 10.6 ± 4.2 10.8 ± 5.3 11.1 ± 4.5 0.75
Ventilatory support needed No. (%) 116 (92.8%) 106 (86.2%) 110 (86.6%) 0.19
Cardiovascular pathologies No. (%) 18 (14.4%) 22 (17.9%) 27 (21.3%) 0.364
Hepatic insufficiency No. (%) 4 (3.2%) 1 (0.8%) 1 (0.8%) 0.22
Immunocompromised No. (%) 17 (13.6%) 12 (9.8%) 19 (15.0%) 0.45
Renal Insufficiency No. (%) 0 2 (1.6%) 6 (4.7%) 0.03
COPD No. (%) 16 (12.8%) 15 (12.2%) 14 (11.0%) 0.91
Baseline SOFA
score > 2
     
 Cardiovascular No. (%) 125 (100%) 123 (100%) 127 (100%) -
 Coagulation No. (%) 3 (2.4%) 9 (7.3%) 20 (15.9%) 0.001
 Liver No. (%) 0 3 (2.6%) 8 (6.7%) 0.01
 Kidney No. (%) 24 (19.4%) 28 (23.1%) 32 (25.6%) 0.50
 Respiratory No. (%) 54 (44.3%) 56 (46.3%) 56 (44.4%) 0.94
Dead at 90 days No. (%) 40 (32.0%) 43 (35.0%) 58 (45.7%) 0.06
  1. SYN-1, syndecan-1; S1P, sphingosine 1-phosphate; IQR, interquartile range; SD, standard deviation; BMI, body mass index; COPD, chronic obstructive pulmonary disease; SOFA, sequential organ failure assessment
  2. *p value for Kruskal–Wallis or Chi2 to compare VE-cadherin tertiles