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Table 2 Patients’ characteristics by tertiles of S1P on day 1

From: Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS

S1P (ng/mL)

Lowest tertile

range: 15.7–73.2

(124)

Middle tertile

range: 73.4–103.3

(124)

Highest tertile

range: 103.4–358.0

(127)

p*

SYN-1

(ng/mL)

     

 Day 1

Median [IQR]

229 [95–401]

222 [95–515]

144 [84–316]

0.02

 Day 2

Median [IQR]

547 [287–1157]

427 [241–998]

339 [206–598]

0.002

 Day 7

Median [IQR]

650 [346–1086]

511 [254–1027]

337 [242–689]

0.001

VE-cadherin

(ng/mL)

     

 Day 1

Median [IQR]

1674 [1250–2172]

1685 [1338–2239]

1714 [1367–2191]

0.58

 Day 2

Median [IQR]

1819 [1489–2330]

1742 [1359–2330]

1706 [1460–2158]

0.79

 Day 7

Median [IQR]

1872 [1614–2356]

1860 [1518–2331]

1819 [1506–2319]

0.85

Sex

     

 Female

No. (%)

60 (48.4%)

56 (45.2%)

48 (37.8%)

0.22

Age (year)

Mean ± SD

67.2 ± 13.9

69.9 ± 14.4

68.9 ± 13.1

0.13

BMI (kg/m2)

Mean ± SD

25.8 ± 5.3

27.8 ± 6.6

26.4 ± 5.0

0.04

Mean arterial pressure (mmHg)

Mean ± SD

72.4 ± 14.0

71.7 11.7

74.7 ± 13.4

0.13

Heart rate (bpm)

Mean ± SD

109 ± 22

103 ± 20

103 ± 22

0.03

Urine output (mL/h)

Median[IQR]

60 [30–100]

50 [20–100]

70 [36–120]

0.05

Hemoglobin (g/dL)

Mean ± SD

11.1 ± 1.6

11.0 ± 1.8

11.0 ± 1.8

0.70

PaO2/FiO2

Median [IQR]

198 [129–281]

201 [130–275]

202 [140–298]

0.41

Venous oxygen saturation (%)

Mean ± SD

73.5 ± 9.5

72.9 ± 10.3

74.1 ± 8.4

0.87

Central venous pressure (mmHg)

Mean ± SD

10.5 ± 7.1

11.1 ± 4.2

11.0 ± 4.9

0.63

Ventilatory support needed

No. (%)

107 (86.3%)

115 (92.7%)

110 (86.6%)

0.20

Cardiovascular pathologies

No. (%)

17 (13.7%)

26 (21.0%)

24 (18.9%)

0.31

Hepatic insufficiency

No. (%)

4 (3.2%)

2 (1.6%)

0

0.13

Immunocompromised

No. (%)

24 (19.4%)

13 (10.5%)

11 (8.7%)

0.03

Renal insufficiency

No. (%)

3 (2.4%)

3 (2.4%)

2 (1.6%)

0.87

COPD

No. (%)

9 (7.3%)

18 (14.5%)

18 (14.2%)

0.14

Baseline SOFA

score > 2

     

 Cardiovascular

No. (%)

124 (100%)

124 (100%)

127 (100%)

-

 Coagulation

No. (%)

18 (14.8%)

11 (8.9%)

3 (2.4%)

0.002

 Liver

No. (%)

4 (3.5%)

4 (3.3%)

3 (2.5%)

0.88

 Kidney

No. (%)

29 (24.2%)

33 (26.6%)

22 (17.5%)

0.20

 Respiratory

No. (%)

55 (45.5%)

57 (46.3%)

54 (43.2%)

0.88

Dead at 90 days

No. (%)

45 (36.3%)

50 (40.3%)

46 (36.2%)

0.75

  1. SYN-1, syndecan-1; S1P, sphingosine 1-phosphate; IQR, interquartile range; SD, standard deviation; BMI, body mass index; COPD, chronic obstructive pulmonary disease; SOFA, sequential organ failure assessment
  2. *p value for Kruskal–Wallis or Chi2 to compare S1P tertiles
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Critical Care

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