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Table 2 Patients’ characteristics by tertiles of S1P on day 1

From: Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS

S1P (ng/mL) Lowest tertile
range: 15.7–73.2
(124)
Middle tertile
range: 73.4–103.3
(124)
Highest tertile
range: 103.4–358.0
(127)
p*
SYN-1
(ng/mL)
     
 Day 1 Median [IQR] 229 [95–401] 222 [95–515] 144 [84–316] 0.02
 Day 2 Median [IQR] 547 [287–1157] 427 [241–998] 339 [206–598] 0.002
 Day 7 Median [IQR] 650 [346–1086] 511 [254–1027] 337 [242–689] 0.001
VE-cadherin
(ng/mL)
     
 Day 1 Median [IQR] 1674 [1250–2172] 1685 [1338–2239] 1714 [1367–2191] 0.58
 Day 2 Median [IQR] 1819 [1489–2330] 1742 [1359–2330] 1706 [1460–2158] 0.79
 Day 7 Median [IQR] 1872 [1614–2356] 1860 [1518–2331] 1819 [1506–2319] 0.85
Sex      
 Female No. (%) 60 (48.4%) 56 (45.2%) 48 (37.8%) 0.22
Age (year) Mean ± SD 67.2 ± 13.9 69.9 ± 14.4 68.9 ± 13.1 0.13
BMI (kg/m2) Mean ± SD 25.8 ± 5.3 27.8 ± 6.6 26.4 ± 5.0 0.04
Mean arterial pressure (mmHg) Mean ± SD 72.4 ± 14.0 71.7 11.7 74.7 ± 13.4 0.13
Heart rate (bpm) Mean ± SD 109 ± 22 103 ± 20 103 ± 22 0.03
Urine output (mL/h) Median[IQR] 60 [30–100] 50 [20–100] 70 [36–120] 0.05
Hemoglobin (g/dL) Mean ± SD 11.1 ± 1.6 11.0 ± 1.8 11.0 ± 1.8 0.70
PaO2/FiO2 Median [IQR] 198 [129–281] 201 [130–275] 202 [140–298] 0.41
Venous oxygen saturation (%) Mean ± SD 73.5 ± 9.5 72.9 ± 10.3 74.1 ± 8.4 0.87
Central venous pressure (mmHg) Mean ± SD 10.5 ± 7.1 11.1 ± 4.2 11.0 ± 4.9 0.63
Ventilatory support needed No. (%) 107 (86.3%) 115 (92.7%) 110 (86.6%) 0.20
Cardiovascular pathologies No. (%) 17 (13.7%) 26 (21.0%) 24 (18.9%) 0.31
Hepatic insufficiency No. (%) 4 (3.2%) 2 (1.6%) 0 0.13
Immunocompromised No. (%) 24 (19.4%) 13 (10.5%) 11 (8.7%) 0.03
Renal insufficiency No. (%) 3 (2.4%) 3 (2.4%) 2 (1.6%) 0.87
COPD No. (%) 9 (7.3%) 18 (14.5%) 18 (14.2%) 0.14
Baseline SOFA
score > 2
     
 Cardiovascular No. (%) 124 (100%) 124 (100%) 127 (100%) -
 Coagulation No. (%) 18 (14.8%) 11 (8.9%) 3 (2.4%) 0.002
 Liver No. (%) 4 (3.5%) 4 (3.3%) 3 (2.5%) 0.88
 Kidney No. (%) 29 (24.2%) 33 (26.6%) 22 (17.5%) 0.20
 Respiratory No. (%) 55 (45.5%) 57 (46.3%) 54 (43.2%) 0.88
Dead at 90 days No. (%) 45 (36.3%) 50 (40.3%) 46 (36.2%) 0.75
  1. SYN-1, syndecan-1; S1P, sphingosine 1-phosphate; IQR, interquartile range; SD, standard deviation; BMI, body mass index; COPD, chronic obstructive pulmonary disease; SOFA, sequential organ failure assessment
  2. *p value for Kruskal–Wallis or Chi2 to compare S1P tertiles