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Table 1 Patients’ characteristics by tertiles of syndecan-1 on day 1

From: Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS

SYN-1 (ng/mL) Lowest tertile
range:21–110
(124)
Middle tertile
range:111–298
(124)
Highest tertile
range:304–2560
(127)
P*
S1P (ng/mL)     
 Day 1 Median [IQR] 93 [70–132] 86 [64–119] 82 [62–105] 0.07
 Day 2 Median [IQR] 90 [72–131] 90 [64–122] 84 [67–118] 0.48
 Day 7 Median [IQR] 97 [70–139] 89 [67–124] 93 [73–130] 0.33
VE-cadherin (ng/mL)     
 Day 1 Median [IQR] 1469 [1172–1786] 1729 [1396–2279] 1920 [1549–2489] 1.5 × 10–8
 Day 2 Median [IQR] 1531 [1247–1969] 1809 [1465–2314] 2072 [1640–2674] 2.1 × 10–10
 Day 7 Median [IQR] 1708 [1471–2097] 1871 [1523–2315] 2073 [1630–2477] 0.001
Sex      
 Female No. (%) 56 (42.5%) 53 (42.7%) 55 (43.3%) 0.92
Age (year) Mean ± SD 69.8 ± 13.5 69.0 ± 14.1 67.1 ± 13.9 0.22
BMI (kg/m2) Mean ± SD 26.4 ± 6.2 26.1 ± 5.1 27.5 ± 5.8 0.06
Mean arterial pressure (mmHg) Mean ± SD 73 ± 12.4 75 ± 13.2 71 ± 13.6 0.13
Heart rate (bpm) Mean ± SD 101 ± 20.6 104 ± 22.9 111 ± 20.3 0.001
Urine output (mL/h) Median[IQR] 73 [40–100] 63 [30–100] 50 [20–100] 0.007
Hemoglobin (g/dL) Mean ± SD 11.1 ± 1.8 10.9 ± 1.7 11.1 ± 1.7 0.69
PaO2/FiO2 Median[IQR] 214 [143–322] 199 [130–279] 193 [133–266] 0.25
Venous oxygen saturation (%) Mean ± SD 74.1 ± 8.1 73.1 ± 9.7 73.2 ± 10.3 0.88
Central venous pressure (mmHg) Mean ± SD 10.4 ± 4.4 11.5 ± 4.9 10.8 ± 4.6 0.16
Ventilatory support needed No. (%) 108 (87.1%) 109 (87.9%) 115 (90.6%) 0.67
Cardiovascular pathologies No. (%) 15 (12.1%) 24 (19.4%) 28 (22.0%) 0.11
Hepatic insufficiency No. (%) 4 (3.2%) 1 (0.8%) 1 (0.8%) 0.21
Immunocompromised No. (%) 16 (12.9%) 16 (12.9%) 16 (12.6%) 1
Renal insufficiency No. (%) 0 5 (4.0%) 3 (2.4%) 0.09
COPD No. (%) 18 (14.5%) 15 (12.1%) 12 (9.4%) 0.47
Baseline SOFA
score > 2
     
 Cardiovascular No. (%) 124 (100%) 124 (100%) 127 (100%) -
 Coagulation No. (%) 4 (3.2%) 8 (6.5%) 20 (15.9%) 0.001
 Liver No. (%) 0 2 (1.7%) 9 (7.7%) 0.002
 Kidney No. (%) 19 (15.3%) 25 (20.7%) 40 (32.0%) 0.006
 Respiratory No. (%) 49 (39.5%) 57 (47.5%) 60 (48.0%) 0.32
Dead at 90 days No. (%) 33 (26.6%) 46 (37.1%) 62 (48.8%) 0.001
  1. SYN-1, syndecan-1; S1P, sphingosine 1-phosphate; IQR, Interquartile range; SD, standard deviation; BMI, body mass index; COPD, chronic obstructive pulmonary disease; SOFA, sequential organ failure assessment
  2. *p value for Kruskal–Wallis or Chi2 to compare Syndecan-1 tertiles