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Table 1 Patients’ characteristics by tertiles of syndecan-1 on day 1

From: Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS

SYN-1 (ng/mL)

Lowest tertile

range:21–110

(124)

Middle tertile

range:111–298

(124)

Highest tertile

range:304–2560

(127)

P*

S1P (ng/mL)

    

 Day 1

Median [IQR]

93 [70–132]

86 [64–119]

82 [62–105]

0.07

 Day 2

Median [IQR]

90 [72–131]

90 [64–122]

84 [67–118]

0.48

 Day 7

Median [IQR]

97 [70–139]

89 [67–124]

93 [73–130]

0.33

VE-cadherin (ng/mL)

    

 Day 1

Median [IQR]

1469 [1172–1786]

1729 [1396–2279]

1920 [1549–2489]

1.5 × 10–8

 Day 2

Median [IQR]

1531 [1247–1969]

1809 [1465–2314]

2072 [1640–2674]

2.1 × 10–10

 Day 7

Median [IQR]

1708 [1471–2097]

1871 [1523–2315]

2073 [1630–2477]

0.001

Sex

     

 Female

No. (%)

56 (42.5%)

53 (42.7%)

55 (43.3%)

0.92

Age (year)

Mean ± SD

69.8 ± 13.5

69.0 ± 14.1

67.1 ± 13.9

0.22

BMI (kg/m2)

Mean ± SD

26.4 ± 6.2

26.1 ± 5.1

27.5 ± 5.8

0.06

Mean arterial pressure (mmHg)

Mean ± SD

73 ± 12.4

75 ± 13.2

71 ± 13.6

0.13

Heart rate (bpm)

Mean ± SD

101 ± 20.6

104 ± 22.9

111 ± 20.3

0.001

Urine output (mL/h)

Median[IQR]

73 [40–100]

63 [30–100]

50 [20–100]

0.007

Hemoglobin (g/dL)

Mean ± SD

11.1 ± 1.8

10.9 ± 1.7

11.1 ± 1.7

0.69

PaO2/FiO2

Median[IQR]

214 [143–322]

199 [130–279]

193 [133–266]

0.25

Venous oxygen saturation (%)

Mean ± SD

74.1 ± 8.1

73.1 ± 9.7

73.2 ± 10.3

0.88

Central venous pressure (mmHg)

Mean ± SD

10.4 ± 4.4

11.5 ± 4.9

10.8 ± 4.6

0.16

Ventilatory support needed

No. (%)

108 (87.1%)

109 (87.9%)

115 (90.6%)

0.67

Cardiovascular pathologies

No. (%)

15 (12.1%)

24 (19.4%)

28 (22.0%)

0.11

Hepatic insufficiency

No. (%)

4 (3.2%)

1 (0.8%)

1 (0.8%)

0.21

Immunocompromised

No. (%)

16 (12.9%)

16 (12.9%)

16 (12.6%)

1

Renal insufficiency

No. (%)

0

5 (4.0%)

3 (2.4%)

0.09

COPD

No. (%)

18 (14.5%)

15 (12.1%)

12 (9.4%)

0.47

Baseline SOFA

score > 2

     

 Cardiovascular

No. (%)

124 (100%)

124 (100%)

127 (100%)

-

 Coagulation

No. (%)

4 (3.2%)

8 (6.5%)

20 (15.9%)

0.001

 Liver

No. (%)

0

2 (1.7%)

9 (7.7%)

0.002

 Kidney

No. (%)

19 (15.3%)

25 (20.7%)

40 (32.0%)

0.006

 Respiratory

No. (%)

49 (39.5%)

57 (47.5%)

60 (48.0%)

0.32

Dead at 90 days

No. (%)

33 (26.6%)

46 (37.1%)

62 (48.8%)

0.001

  1. SYN-1, syndecan-1; S1P, sphingosine 1-phosphate; IQR, Interquartile range; SD, standard deviation; BMI, body mass index; COPD, chronic obstructive pulmonary disease; SOFA, sequential organ failure assessment
  2. *p value for Kruskal–Wallis or Chi2 to compare Syndecan-1 tertiles
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Critical Care

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