Fig. 5
From: Urinary metabolites predict mortality or need for renal replacement therapy after combat injury
Relationship of various metabolic pathways for AKI and combat injury. Metabolites included in the schematic were either a top 10 VIP metabolite or were statistically significant (p < 0.05). Metabolic pathways: glycolysis, TCA cycle, folate and methionine cycles, Cori and Cahill cycles, gut microbe metabolism, and NAD+ salvage pathway. Bolded metabolites were identified in the 1H-NMR analysis. Metabolites in green were significantly higher in patients who reached the endpoint or mortality/RRT and/or had more severe AKI. Metabolites in red were significantly lower in patients who reached the endpoint or mortality/RRT and/or had more severe AKI