|
Parameter
|
All (N = 45)
|
RM (N = 22)RM (N = 22)
|
Prone position (N = 10)
|
|---|
|
T0
|
T1
|
p value
|
T0
|
T1
|
p value
|
T0
|
T1
|
p value
|
|---|
|
Primary outcome
|
|
rSO2 (%)
|
53 [51–55]
|
52 [49–59]
|
0.692
|
52 [51–54]
|
48.5 [47–50]
|
< 0.0001*
|
53 [52–54]
|
59.5 [59–64]
|
0.005*
|
|
PaO2 /FiO2
|
66 [62–72]
|
71 [67–74]
|
0.002*
|
66 [62–72]
|
67.5 [63–72]
|
0.189
|
62 [56–71]
|
81.5 [76–87]
|
0.005*
|
|
SpO2 (%)
|
88 [87–90]
|
91 [89–92]
|
< 0.0001*
|
88 [87–89]
|
89 [88–91]
|
0.072
|
87 [86–88]
|
93 [89–96]
|
0.005*
|
|
Ventilator settings
|
|
PEEP (cmH2O)
|
12 [11–13]
|
12 [11–13]
|
0.169
|
12 [11–13]
|
12 [10–13]
|
0.157
|
12 [11–13]
|
12 [10–13]
|
0.317
|
|
Pplat (cmH2O)
|
29 [28–30]
|
29 [28–30]
|
0.698
|
29 [28–30]
|
29 [28–30]
|
1.000
|
29 [28–30]
|
29 [28–30]
|
1.000
|
|
VT/PBW (mL/Kg)
|
5.7 [5.5–6.2]
|
5.9 [4.9–6.9]
|
0.086
|
6.7 [6–7.1]
|
6.3 [5.4–6.6]
|
0.001*
|
5.4 [5.1–6.1]
|
6.3 [6–7.1]
|
0.005*
|
|
RR (n/min)
|
26 [24.5–27.5]
|
26 [24.5–28]
|
0.026*
|
25 [24–26]
|
25 [24–26]
|
0.109
|
27.5 [26–28]
|
27.5 [26–28]
|
1.000
|
|
Crs (mL/cmH2O)
|
20.1 [18.2–24.7]
|
19.8 [17.8–23.5]
|
0.615
|
21.6 [19.4–25.2]
|
20.1 [19.6–24.5]
|
0.200
|
14.9 [13.4–18.6]
|
23.4 [19.5–26.4]
|
0.005*
|
|
Neuromonitoring
|
|
ΔcHbi
|
4.3 [3–6]
|
4.7 [2.6–7.7]
|
0.157
|
5 [3.7–6.1]
|
3.2 [2.5–4.6]
|
< 0.0001*
|
4.5 [2.4–6.5]
|
10.2 [8.9–12.4]
|
0.005*
|
|
ΔO2Hbi
|
3.2 [2.7–4.2]
|
2.1 [1.4–5.3]
|
0.991
|
3.7 [2.9–4.4]
|
1.7 [1.3–2.1]
|
< 0.0001*
|
3.5 [2.1–4.6]
|
8 [6.3–8.8]
|
0.005*
|
|
ΔHHbi
|
0.9 [0.3–1.8]
|
2.1 [1.2–2.8]
|
< 0.0001*
|
1.1 [0.8–1.8]
|
1.3 [1.1–2.2]
|
0.001*
|
1 [0.2–1.9]
|
2.3 [2.1–3.9]
|
0.005*
|
|
nICP (mmHg)
|
17 [15.5–19]
|
21 [17–26]
|
< 0.0001*
|
17.5 [15–19]
|
26 [24–28]
|
< 0.0001*
|
16 [15–18]
|
18 [16–20]
|
0.016*
|
|
nCPP (mmHg)
|
55 [51–60]
|
50 [39–59]
|
0.001*
|
54 [50–62]
|
39 [35–44]
|
< 0.0001*
|
55.5 [53–58]
|
60.5 [59–63]
|
0.011*
|
|
ΔSpO2rSO2 (%)
|
36 [37–37
|
38 [33–41]
|
0.001*
|
36 [35–37]
|
41 [38–43]
|
< 0.0001*
|
33.5 [32–35]
|
31.5 [30–33.5]
|
0.134
|
|
Other arterial blood gas values
|
|
pHa
|
7.37 [7.33–7.41]
|
7.38 [7.35–7.41]
|
0.017*
|
7.38 [7.34–7.41]
|
7.38 [7.35–7.42]
|
0.466
|
7.37 [7.34–7.41]
|
7.41 [7.38–7.43]
|
0.024*
|
|
PaCO2 (mmHg)
|
54 [48–64]
|
53 [47–63]
|
< 0.0001*
|
51 [46–56]
|
50 [45–56]
|
0.108
|
53.5 [47–71]
|
53.3 [47–69]
|
0.021*
|
|
Hemodynamics
|
|
Hb (mg/dL)
|
8.5 [8.1–8.8]
|
8.3 [8.1–8.7]
|
0.119
|
8.6 [8.2–8.8]
|
8.4 [8.3–8.8]
|
0.343
|
8.5 [8.1–8.9]
|
8.3 [8.1–8.7]
|
0.321
|
|
MAP (mmHg)
|
72 [68–76.5]
|
71 [65–76]
|
0.013*
|
71.5 [67–76]
|
64 [59–68]
|
< 0.0001*
|
72.5 [68–75]
|
78.5 [71–84]
|
0.005*
|
|
HR (n/min)
|
75 [65–88.5]
|
77 [68–94]
|
0.015*
|
77.5 [68–89]
|
79 [69–91]
|
0.009*
|
77 [75–85]
|
78 [72–83]
|
0.878
|
|
Parameter
|
iNO (N = 9)
|
ECCO2R (N = 4)
|
|---|
|
T0
|
T1
|
p value
|
T0
|
T1
|
p value
|
|---|
|
Primary outcome
|
|
rSO2 (%)
|
53 [51–56]
|
57 [55–59]
|
0.007*
|
59 [55.5–64.5]
|
56 [52.5–62]
|
0.002*
|
|
PaO2 /FiO2
|
65 [67–73]
|
72 [67–73]
|
0.015*
|
75 [74.5–78.5]
|
63.5 [60–69.5]
|
0.009*
|
|
SpO2 (%)
|
89 [88–90]
|
92 [91–93]
|
0.016*
|
93 [91.5–94]
|
89.5 [87.5–91]
|
0.01*
|
|
Ventilator settings
|
|
PEEP (cmH2O)
|
12 [11–14]
|
12 [10–13]
|
0.025*
|
12 [1113]
|
10.5 [10–11]
|
0.103
|
|
Pplat (cmH2O)
|
29 [28–29]
|
29 [28–29]
|
1.000
|
29.5 [28–30.5]
|
29.5 [28–30.5]
|
0.543
|
|
VT/PBW (mL/Kg)
|
5.7 [5.2–7.4]
|
5.9 [5.3–7.2]
|
0.441
|
5.7 [3–6.7]
|
4.3 [3.8–6]
|
0.068
|
|
RR (n/min)
|
25 [20–26]
|
26 [22–26]
|
0.102
|
29 [27–30]
|
29 [27–30]
|
0.225
|
|
Crs (mL/cmH2O)
|
20.8 [19.3–26.5]
|
16.7 [19.6– 26.6]
|
0.086
|
17 [15.9–18.9]
|
13.5 [11.3–15.7]
|
0.465
|
|
Neuromonitoring
|
|
ΔcHbi
|
3.1 [3–4.3]
|
7.1 [7–8.1]
|
0.008*
|
3.6 [2.7–4.2]
|
1.3 [0.7–1.9]
|
0.002*
|
|
ΔO2Hbi
|
2.8 [2.6–3.7]
|
4.7 [4.1–5.2]
|
0.008*
|
3 [2.3–3.4]
|
0.6 [0.2–1.2]
|
0.002*
|
|
ΔHHbi
|
0.4 [0.3–1.2]
|
2.8 [1.9–2.9]
|
0.008*
|
0.6 [0.3–0.8]
|
0.7 [0.4–0.8]
|
0.182
|
|
nICP (mmHg)
|
18 [17–19]
|
17 [16–18]
|
0.033*
|
22.5 [19–26]
|
18.5 [15–23]
|
0.006*
|
|
nCPP (mmHg)
|
59 [54–60]
|
59 [53–60]
|
0.395
|
50.5 [50–52]
|
53 [52–54.5]
|
0.059
|
|
ΔSpO2rSO2 (%)
|
36 [34–37]
|
35 [33––37]
|
0.320
|
34 [29.5–36]
|
33.5 [29–35]
|
0.058
|
|
Other arterial blood gas values
|
|
pHa
|
7.36 [7.35–7.38]
|
7.38 [7.36–7.39]
|
0.031*
|
7.21 [7.19–7.26]
|
7.36 [7.34–7.37]
|
0.008*
|
|
PaCO2 (mmHg)
|
54 [48–68]
|
55[48–67]
|
0.058
|
100 [99–100]
|
72 [70–73]
|
< 0.0001*
|
|
Hemodynamics
|
|
Hb (mg/dL)
|
8.1 [7.9–8.3]
|
8.3 [7.7–8.3]
|
0.432
|
8.1 [7.8–8.5]
|
8.2 [7.9–8.5]
|
0.314
|
|
MAP (mmHg)
|
76 [71–76]
|
75 [70–77]
|
0.248
|
73 [69–78]
|
71.5 [67–77.5]
|
0.141
|
|
HR (n/min)
|
69 [64–75]
|
67 [65–89]
|
0.917
|
65.5 [65–71.5]
|
73 [69.5–78]
|
0.049*
|
- Values are presented as median and Interquartile range if not otherwise specified
- ECCO2R extracorporeal carbon dioxide removal, RM recruitment maneuvers, iNO inhaled nitric oxide, PaO2 partial pressure of oxygen, FiO2 inspired fraction of oxygen ratio, SpO2 oxygen saturation, PEEP positive end-expiratory pressure, Pplat plateau pressure, VT tidal volume, PBW predicted body weight, RR respiratory rate, Crs respiratory system compliance, rSO2 cerebral oxygenation saturation, nICP noninvasive intracranial pressure, nCPP noninvasive cerebral perfusion pressure
- DeltaO2Hbi (ΔO2Hbi), change in the oxygenated component of hemoglobin (Hb); delta HHbi (ΔHHbi), change in the deoxygenated component of Hb; delta cHbi (ΔcHbi), sum of the values of ΔO2Hbi; ΔcHbi = ΔHHbi + ΔO2Hbi; ΔSpO2–rSO2, difference between the value of SpO2 and rSO2; N number
