Table 2 Patient management strategies and outcomes in the included studies

Schmidt [17]

3376/4643

(72%)

1966/2224

(88%)

1556/2223

(70%)

425/2224

(19%)

235/2153

(11%)

1298/4244 (31%)

Gupta [21]

1859/2215 (84%)

909/1859 (49%)

852/1859 (46%)

212/1859 (11%)

61/1859 (3.3%)

875/2215 (39.5%)

Grasselli [22]

2929/3355 (87%)

64/3857 (1.7%)

1769/3988 (44%)

91/3988 (2.3%)

2049/3988 (51%)

Ferrando [19]

742/742 (100%)

536/742 (72%)

564/735 (77%)

21/738 (2.8%)

241/742 (32%)

100 (13%)

401/742 (54%)

Botta [23]

553/553

(100%)

183/487 (38%)

283/530 (53%)

2/553 (< 1%)

203/530 (38%)

Grasselli [18]

301/301 (100%)

93/261

(35.6%)

Schenck [26]

267/267 (100%)

161/267 (60%)

108/267 (40%)

49/267 (18%)

140/267 (52%)

Cummings [20]

203/257 (79%)

51/203 (25%)

35/203 (17%)

22/203 (11%)

6/203 (3%)

101/257 (39%)

Roedl [24]

167/223 (75%)

37/167 (22%)

108/167 (64%)

19/167 (11%)

20/223 (9%)

78/223 (35%)

Auld [25]

165/217 (76%)

22/165 (13%)

4/165 (2%)

62/217 (29%)

8/217 (4%)

147/217 (68%)

Mitra [8]

74/117 (63%)

50/74 (68%)

21/74 (28%)

8/74 (11%)

3/74 (4%)

18/117 (15%)

12/117 (10%)

87/117 (74%)

Pandya [35]

75/75 (100%)

37/75 (49%)

Cavayas [41]

43/75

(56%)

16/43 (37%)

11/43 (26%)

15/43 (35%)

1 (2%)

17/75 (23%)

58/75 (77%)

Zangrillo [36]

73/73 (100%)

53/70 (76%)

55/72 (76%)

5/73 (7%)

17/73 (23%)

33/73 (45%)

23/73 (32%)

Ziehr [28]

66/66 (100%)

28/66 (42%)

31/66 (47%)

18/66 (27%)

3/66 (5%)

11/66 (17%)

5/66 (8%)

50/66 (76%)

Sinha [27]

39/39 (100%)

17/39 (44%)

Laverdure [37]

36/36 (100%)

29/36 (81%)

9/39 (25%)

7 (19%)

4/36 (11%)

7/36 (19%)

25/36 (69%)

Bhatraju [29]

18/24 (75%)

7/18 (39%)

5/18 (28%)

5/18 (28%)

0

12/24 (50%)

Pedersen [38]

17/17 (100%)

5/17 (29%)

0

7/17 (41%)

6/17 (35%)

4/17 (24%)

Liu X [40]

8/8 (100%)

0/8

3/8 (37%)

5/8 (63%)

LUNGSAFE [50]

21.7%

7.9%

7.7%

3.2%

35.3%