Table 1 Baseline characteristics

Number of participants (n; %)

17

34

–

Female sex (n; %)

9 (53)

8 (24)

0.06

Age (years, median (IQR))

51 (33–72)

66 (56–78)

0.06

BMI (kg/m², median (IQR))

23 (21.5–24.9)

25.8 (21.9–29.2)

0.06

Duration of sepsis at study inclusion (days, median (IQR))*

–

2 (1–4)

–

SOFA score (median (IQR))

–

10 (8–13)

–

Number of dysfunctional organs (median (IQR))

–

4 (3–5)

–

Organ replacement therapy (n; %)

–

22 (64.7)

–

Mechanical ventilation (n; %)

–

21 (61.8)

–

Acute dialysis (n; %)

–

6 (17.7)

–

Vasopressors (n; %)

–

26 (76.4)

–

Norepinephrine dose (μg/kg/min)

–

0.06 (0.02–0.14)

–

Septic shock (n; %)*

–

6 (17.7)

–

Inhospital mortality (n; %)

13 (38.2)

–

CCI score (median (IQR))

–

2 (1–3)

–

Macrocirculation data (median (IQR))

MAP (mmHg)

95.3 (86–98.7)

71.8 (66.5–81.1)

< 0.0001

Heart Rate (pulse/min)

72 (65–83)

90 (75–102)

0.0002

Respiratory Rate (breaths/min)

14 (12–15)

21 (18–26)

< 0.0001

Temperature (°C)

36.6 (36.5–36.9)

36.9 (36.4–37.7)

0.08

Laboratory data (median (IQR))

CRP (mg/dl)

0.5

22.4 (16.9–33.3)

< 0.0001

IL-6 (ng/ml)

2 (2–3)

452 (137–1121)

< 0.0001

PCT (ng/ml)

0.05 (0.04–0.07)

17.43 (2.04–52.44)

< 0.0001

pH

–

7.41 (7.35–7.45)

–

Lactate (mmol/l)

1.1 (0.80–1.4)

1.70 (1.08–2)

0.004