EPaNIC patients with surgical contraindication to enteral nutrition and available plasma | Early-PN | Late-PN | P-value |
---|---|---|---|
Baseline characteristics time cohort (n = 110) | n = 55 | n = 55 |  |
 Age (years)—median (IQR) | 68.1 (55.9–77.8) | 66.1 (55.5–73.6) | 0.45 |
 BMI—median (IQR)a | 25.3 (22.2–29.2) | 25.7 (22.4–33.7) | 0.61 |
 Malignancy—no. (%) | 31 (56.3) | 32 (58.1) | 1.00 |
 APACHEII score—median (IQR)b | 36 (28–39) | 35 (31–39) | 0.75 |
 NRS score—median (IQR)c | 4 (3–6) | 4 (4–6) | 0.49 |
 Diagnostic categories |  |  | 0.69 |
  (Complications after) abdominal/pelvic surgery—no. (%) | 36 (65.4) | 33 (60.0) | |
  (Complications after) thoracic surgery—no. (%) | 19 (34.5) | 22 (40.0) | |
Baseline characteristics total cohort (n = 509) | n = 252 | n = 257 |  |
 Age (years)—median (IQR) | 64.4 (54.4–73.5) | 64.4 (53.7–73.0) | 0.99 |
 BMI—median (IQR)a | 24.5 (22.2–28.3) | 24.6 (22.0–28.7) | 0.89 |
 Malignancy—no. (%) | 161 (63.8) | 154 (59.9) | 0.36 |
 APACHEII score—median (IQR)b | 27 (16–37) | 28 (18–36) | 0.86 |
 NRS score—median (IQR)c | 4 (3–6) | 4 (3–5) | 0.34 |
 Diagnostic categories |  |  | 0.70 |
  (Complications after) abdominal/pelvic surgery—no. (%) | 168 (66.6) | 177 (68.8) | |
  (Complications after) thoracic surgery—no. (%) | 84 (33.3) | 80 (31.1) | |
Outcome of total cohort (n = 509) | n = 252 | n = 257 |  |
 Hazard ratio (95% CI) for time to live ICU discharge |  | 1.23 (1.02–1.48) | 0.024 |
 Alive ICU discharge within 8 days—no. (%) | 125 (49.6) | 151 (58.7) | 0.041 |
 New infection—no. (%) | 103 (40.2) | 78 (29.8) | 0.009 |