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Table 4 Ability of different variables to detect preload responsiveness

From: Do changes in pulse pressure variation and inferior vena cava distensibility during passive leg raising and tidal volume challenge detect preload responsiveness in case of low tidal volume ventilation?

  r versus PLR-induced changes in CI p versus 0.5 AUROC sd p versus 0.50 Cut-off Se 95% CI Sp 95% CI + PV 95% CI − PV 95% CI + LR 95% CI − LR 95% CI
GEDV (mL/m2)    0.59 0.10 0.47              
CVP (mmHg)    0.56 0.11 0.57              
IVC max diameter (mm)    0.58 0.11 0.49              
PPV (%)    0.66 0.10 0.10              
SVV (%)    0.61 0.10 0.10              
IVCDV (%)    0.64 0.11 0.20              
ΔPPVPLR (% change) − 0.77 < 0.01 0.98 0.02 < 0.01 ≤ − 20% 100 78–100 93 61–100 94 69–99 100   15.0 2.3–99.6 0.0  
ΔPPVPLR (abs. change) − 0.70 < 0.01 0.98 0.02 < 0.01 ≤ − 2 points 93 68–100 93 68–100 94 69–99 94 69–99 14.0 2.1–93.4 0.1 0.0–0.5
ΔPPVVt (% change) 0.53 < 0.01 0.94 0.04 < 0.01 > 20% 93 68–100 87 59–98 87 66–96 94 69–99 7.0 1.9–25.6 0.1 0.0–0.5
ΔPPVVt (abs. change) 0.71 < 0.01 0.98 0.02 < 0.01 > 1 point 93 68–100 100 78–100 100   94 69–99    0.1 0.0–0.5
ΔSVVPLR (% change) − 0.66 < 0.01 0.90 0.07 < 0.01 ≤ − 19% 80 52–96 100 78–100 100   83 65–93 5.5 1.5–20.7 0.3 0.1–0.7
ΔSVVPLR (abs. change) − 0.73 < 0.01 0.88 0.07 < 0.01 ≤ − 2 points 73 45–92 100 78–100 100   79 62–90    0.3 0.1–0.6
ΔSVVVt (% change) 0.07 0.69 0.82 0.08 < 0.01 > 20% 100 78–100 67 38–88 70 55–81 75 60–86 3.0 1.5–6.1 0.0  
ΔSVVVt (abs. change) 0.21 0.26 0.94 0.04 < 0.01 > 1 point 93 68–100 73 45–92 78 60–89 100   3.5 1.5–8.2 0.1 0.0–0.6
ΔIVCDVPLR (% change) − 0.50 < 0.01 0.76 0.10 < 0.01 ≤ − 24% 73 45–92 87 85 83 59–95 77 58–89 5.5 1.5–20.7 0.3 0.1–0.7
ΔIVCDVPLR (abs. change) − 0.30 0.09 0.56 0.11 0.60              
ΔIVCDVVt (% change) 0.52 < 0.01 0.88 0.06 < 0.01 > 4% 100 78–100 67 38–88 75 60–86 100   3 1.5–6.1 0.0  
ΔIVCDVVt (abs. change) 0.57 < 0.01 0.92 0.05 < 0.01 > 1 point 100 78–100 60 32–84 71 57–83 100   2.5 1.3–4.6 0.0  
  1. AUROC area under the receiver operating characteristic curve, CI confidence interval, GEDV global end-diastolic volume indexed for body surface, IVC inferior vena cava, IVCDV respiratory variation of the diameter of the inferior vena cava, PPV pulse pressure variation, Se sensitivity, sd standard deviation, Sp specificity, SVV stroke volume variation, + PV positive predictive value, − PV negative predictive value, + LR positive likelihood ratio, − LR negative likelihood ratio, ΔPPVPLR changes in pulse pressure variation induced by passive leg raising, ΔSVVPLR changes in stroke volume variation induced by passive leg raising, ΔIVCDVPLR changes in the respiratory variation of the diameter of the inferior vena cava induced by a tidal volume challenge, ΔPPVVt changes in pulse pressure variation induced by a tidal volume challenge, ΔSVVVt changes in stroke volume variation induced by a tidal volume challenge, ΔIVCDVVt changes in the respiratory variation of the diameter of the inferior vena cava induced by a tidal volume challenge