Do changes in pulse pressure variation and inferior vena cava distensibility during passive leg raising and tidal volume challenge detect preload responsiveness in case of low tidal volume ventilation?

Taccheri, Temistocle; Gavelli, Francesco; Teboul, Jean-Louis; Shi, Rui; Monnet, Xavier

doi:10.1186/s13054-021-03515-7

Critical Care

Table 4 Ability of different variables to detect preload responsiveness

From: Do changes in pulse pressure variation and inferior vena cava distensibility during passive leg raising and tidal volume challenge detect preload responsiveness in case of low tidal volume ventilation?

	r versus PLR-induced changes in CI	p versus 0.5	AUROC	sd	p versus 0.50	Cut-off	Se	95% CI	Sp	95% CI	+ PV	95% CI	− PV	95% CI	+ LR	95% CI	− LR	95% CI
GEDV (mL/m²)			0.59	0.10	0.47
CVP (mmHg)			0.56	0.11	0.57
IVC max diameter (mm)			0.58	0.11	0.49
PPV (%)			0.66	0.10	0.10
SVV (%)			0.61	0.10	0.10
IVCDV (%)			0.64	0.11	0.20
ΔPPV_PLR (% change)	− 0.77	< 0.01	0.98	0.02	< 0.01	≤ − 20%	100	78–100	93	61–100	94	69–99	100		15.0	2.3–99.6	0.0
ΔPPV_PLR (abs. change)	− 0.70	< 0.01	0.98	0.02	< 0.01	≤ − 2 points	93	68–100	93	68–100	94	69–99	94	69–99	14.0	2.1–93.4	0.1	0.0–0.5
ΔPPV_Vt (% change)	0.53	< 0.01	0.94	0.04	< 0.01	> 20%	93	68–100	87	59–98	87	66–96	94	69–99	7.0	1.9–25.6	0.1	0.0–0.5
ΔPPV_Vt (abs. change)	0.71	< 0.01	0.98	0.02	< 0.01	> 1 point	93	68–100	100	78–100	100		94	69–99			0.1	0.0–0.5
ΔSVV_PLR (% change)	− 0.66	< 0.01	0.90	0.07	< 0.01	≤ − 19%	80	52–96	100	78–100	100		83	65–93	5.5	1.5–20.7	0.3	0.1–0.7
ΔSVV_PLR (abs. change)	− 0.73	< 0.01	0.88	0.07	< 0.01	≤ − 2 points	73	45–92	100	78–100	100		79	62–90			0.3	0.1–0.6
ΔSVV_Vt (% change)	0.07	0.69	0.82	0.08	< 0.01	> 20%	100	78–100	67	38–88	70	55–81	75	60–86	3.0	1.5–6.1	0.0
ΔSVV_Vt (abs. change)	0.21	0.26	0.94	0.04	< 0.01	> 1 point	93	68–100	73	45–92	78	60–89	100		3.5	1.5–8.2	0.1	0.0–0.6
ΔIVCDV_PLR (% change)	− 0.50	< 0.01	0.76	0.10	< 0.01	≤ − 24%	73	45–92	87	85	83	59–95	77	58–89	5.5	1.5–20.7	0.3	0.1–0.7
ΔIVCDV_PLR (abs. change)	− 0.30	0.09	0.56	0.11	0.60
ΔIVCDV_Vt (% change)	0.52	< 0.01	0.88	0.06	< 0.01	> 4%	100	78–100	67	38–88	75	60–86	100		3	1.5–6.1	0.0
ΔIVCDV_Vt (abs. change)	0.57	< 0.01	0.92	0.05	< 0.01	> 1 point	100	78–100	60	32–84	71	57–83	100		2.5	1.3–4.6	0.0

AUROC area under the receiver operating characteristic curve, CI confidence interval, GEDV global end-diastolic volume indexed for body surface, IVC inferior vena cava, IVCDV respiratory variation of the diameter of the inferior vena cava, PPV pulse pressure variation, Se sensitivity, sd standard deviation, Sp specificity, SVV stroke volume variation, + PV positive predictive value, − PV negative predictive value, + LR positive likelihood ratio, − LR negative likelihood ratio, ΔPPV_PLR changes in pulse pressure variation induced by passive leg raising, ΔSVV_PLR changes in stroke volume variation induced by passive leg raising, ΔIVCDV_PLR changes in the respiratory variation of the diameter of the inferior vena cava induced by a tidal volume challenge, ΔPPV_Vt changes in pulse pressure variation induced by a tidal volume challenge, ΔSVV_Vt changes in stroke volume variation induced by a tidal volume challenge, ΔIVCDV_Vt changes in the respiratory variation of the diameter of the inferior vena cava induced by a tidal volume challenge

Back to article page

ISSN: 1364-8535

Contact us

Submission enquiries: journalsubmissions@springernature.com