Do changes in pulse pressure variation and inferior vena cava distensibility during passive leg raising and tidal volume challenge detect preload responsiveness in case of low tidal volume ventilation?

Table 1 Patient characteristics at baseline

	Preload responders (n = 15)	Preload non-responders (n = 15)	p value
Age (years)	63 ± 18	70 ± 10	0.37
Male gender (n, %)	12 (80.0)	11 (73.3)	0.32
SAPS2	52 ± 15	56 ± 14	0.29
Mortality (n, %)	7 (46.7)	6 (40.0)	1.00
Septic shock (n, %)	11 (73.3)	12 (80.0)	0.14
Cardiogenic shock (n, %)	2 (13.3)	2 (13.3)	0.55
Hypovolemic shock (n, %)	1 (7.2)	1 (7.2)	1.00
Vasoplegic shock (non-septic) (n, %)	1 (7.2)	0 (0.0)	0.12
CRRT (n, %)	3 (20.0)	4 (26.7)	0.18
ARDS (n, %)	6 (40.0)	5 (33.3)	0.47
Lactate (mmol/L)	1.8 ± 0.6	1.3 ± 0.6	0.88
PaO₂/FiO₂	228 ± 105	276 ± 105	0.55
PEEP (cmH₂O)	10.7 ± 3.6	10.4 ± 3.0	0.63
C_rs (mL/cmH₂O)	31 ± 12	32 ± 13	0.66
Acute cor pulmonale (n, %)	0 (0.0)	0 (0.0)	1.00
LVEF (%)	45 ± 9	49 ± 11	0.67
Patients receiving norepinephrine (n, %)	15 (100.0)	15 (100.0)	1.00
Dose of norepinephrine (µg/kg/min)	1.2 ± 0.6	0.6 ± 0.4	0.02

P values in bold: < 0.05
ARDS acute respiratory distress syndrome, CRRT continuous renal replacement therapy, C_rs compliance of the respiratory system, LVEF left ventricular ejection fraction, PaO₂/FiO₂ ratio of the arterial oxygen partial pressure over the oxygen inspired fraction, PEEP positive end-expiratory pressure, SAPS simplified acute physiologic score

ISSN: 1364-8535