Frailty status among older critically ill patients with severe acute kidney injury

Table 2 Multivariable Cox regression model for 90-day mortality in the OPTIMAL-AKI cohort

Variables	Crude hazard ratio (95% CI)	p Value	Adjusted hazard ratio (95% CI)	p Value
Frailty	1.61 (1.23, 2.10)	< 0.001	1.49 (1.11, 2.01)	0.008
Age	1.03 (1.01, 1.04)	0.003	1.02 (1.01, 1.04)	0.012
Sex (female)	0.92 (0.72, 1.19)	0.533	0.92 (0.71, 1.20)	0.560
Charlson score	1.04 (0.99, 1.10)	0.136	1.04 (0.98, 1.10)	0.180
Baseline eGFR per 10 ml/min	1.02 (0.98, 1.06)	0.294	1.03 (0.98, 1.07)	0.260
Peak Serum Creatinine per 50 umol/L	0.97 (0.94, 0.996)	0.026	0.98 (0.95, 1.01)	0.120
SOFA score	1.07 (1.03, 1.10)	< 0.001	1.05 (1.02 1.10)	0.004
APACHE II score	1.04 (1.02, 1.05)	< 0.001	1.06 (1.03, 1.08)	< 0.001
APACHE II score * time^a	NA	NA	0.998 (0.998, 0.999)	< 0.001

^aWe detected non-proportional hazards for APACHE II scores (non-proportional across time) and accounted for this non-proportionality by modelling the interaction between APACHE II score and time.
APACHE II: acute physiology and chronic health evaluation II, eGFR: estimated glomerular filtration rate, SOFA: sequential organ failure assessment

ISSN: 1364-8535