Table 1 Summary of patient characteristics stratified by frailty status at baseline
From: Frailty status among older critically ill patients with severe acute kidney injury
Variables | Frail 141(30.5%) | Not frail 321 (69.5%) | p value | Missing values (%) |
|---|---|---|---|---|
Demographic information | ||||
Age (mean [SD]), years | 77.4 (8.1) | 74.3 (6.7) | < 0.001 | 0.0 |
Female sex, (n, %) | 74 (52.5) | 114 (35.5) | 0.001 | 0.0 |
Charlson score, (median [IQR]) | 2.0 (1.0, 4.0) | 3.0 (2.0, 5.0) | < 0.001 | 0.2 |
Comorbid diseases, (n, %) | ||||
Congestive heart failure | 44 (31.2) | 67 (20.9) | 0.024 | 0.2 |
Chronic obstructive pulmonary disease | 46 (32.6) | 85 (26.6) | 0.223 | 0.2 |
Connective tissue disease | 11 (7.8) | 16 (5.0) | 0.335 | 0.2 |
Diabetes mellitus | 59 (41.8) | 123 (38.4) | 0.558 | 0.2 |
Peripheral vascular disease | 30 (21.3) | 41 (12.8) | 0.029 | 0.2 |
Any cancer | 26 (18.4) | 63 (19.7) | 0.853 | 0.2 |
Chronic liver disease | 8 (5.7) | 8 (2.5) | 0.150 | 0.2 |
Functional status | ||||
Cognition impairment, (n, %) | ||||
Dementia | 18 (13.8) | 2 (0.7) | ||
Impaired—not demented | 44 (33.8) | 28 (9.5) | < 0.001 | 13.0 |
No impairment | 68 (52.3) | 266 (89.9) | ||
Pre-hospital location | ||||
Home—independent | 45 (32.1) | 283 (88.4) | ||
Home—with assistance | 72 (51.4) | 29 (9.1) | < 0.001 | 2.8 |
Assisted living | 23 (16.4) | 8 (2.5) | ||
Hospitalized in prior 6 months, (n, %) | 66 (46.8) | 110 (34.3) | 0.014 | 1.8 |
Current illness | ||||
Primary diagnostic category, (n, %) | ||||
Cardiovascular | 38 (27.0) | 83 (26.2) | ||
Respiratory | 29 (20.6) | 64 (20.2) | ||
Gastrointestinal/hepatic | 12 (8.5) | 42 (13.2) | ||
Metabolic/endocrine | 11 (7.8) | 28 (8.8) | 0.068 | 0.8 |
Neurologic | 5 (3.5) | 3 (0.9) | ||
Hematologic/oncologic | 0 (0.0) | 8 (2.5) | ||
Sepsis | 45 (31.9) | 79 (24.9) | ||
Trauma | 1 (0.7) | 10 (3.2) | ||
APACHE II score (mean [SD]) | 27.8 (8.7) | 28.4 (8.8) | 0.513 | 3.6 |
SOFA score (mean [SD]) | 9.8 (4.0) | 10.9 (4.3) | 0.011 | 4.0 |
Mechanical ventilation (n, %) | 87 (63.5) | 206 (66.7) | 0.588 | 3.4 |
Vasoactive support (n, %) | 89 (65.0) | 212 (68.6) | 0.517 | 3.4 |
Blood transfusion (n, %) | 17 (12.4) | 64 (20.7) | 0.049 | 3.4 |
Total parenteral nutrition (n, %) | 4 (2.9) | 16 (5.2) | 0.415 | 3.4 |
Baseline serum creatinine, (median [IQR]) | 97.0 (75.0, 133.0) | 95.0 (72.0, 141.0) | 0.972 | 0.6 |
Baseline eGFR, (mean [SD]) | 56.1 (31.7) | 55.7 (30.9) | 0.888 | 0.6 |
Worst KDIGO AKI stage, (n, %) | ||||
Stage 2 | 28 (19.9) | 58 (18.1) | 0.756 | 0.2 |
Stage 3 | 113 (80.1) | 262 (81.9) | ||
Receipt of RRT (n, %) | 53 (37.6) | 165 (51.4) | 0.006 | 0.0 |
Peak BUN, (median [IQR]) | 24.9 (16.5, 33.3) | 27.9 (18.9, 38.0) | 0.034 | 2.4 |
Peak serum creatinine, (median [IQR]) | 305.0 (208.0, 442.0) | 354.0 (242.0, 493.0) | 0.006 | 0.0 |