Table 2 Treatments and (ICU) LOS by 2-week cohorts
|  | Overall (n = 620) | First period (n = 35) | Second period (n = 168) | Third period (n = 164) | Fourth period (n = 125) | Fifth period (n = 94) | Sixth period (n = 34) | P value |
|---|---|---|---|---|---|---|---|---|
Date range | Mar 01–May 15 | Mar 01–Mar 14 | Mar 15–Mar 28 | Mar 29–April 11 | April 12–April 25 | April 26–May 09 | May 10–May 15 | |
Hydroxychloroquine, n (%) | 321 (51.8) | 15 (42.9) | 127 (75.6) | 99 (60.4) | 59 (47.2) | 17 (18.1) | 4 (11.8) | < 0.001 |
Remdesivir, n (%) | 109 (17.6) | 4 (11.4) | 31 (18.5) | 33 (20.1) | 11 (8.8) | 24 (25.5) | 6 (17.6) | 0.029 |
Tocilizumab, n (%) | 88 (14.2) | 1 (2.9) | 22 (13.1) | 27 (16.5) | 23 (18.4) | 11 (11.7) | 4 (11.8) | 0.220 |
Dexamethasone, n (%) | 28 (4.5) | 0 (0.0) | 10 (6.0) | 6 (3.7) | 7 (5.6) | 4 (4.3) | 1 (2.9) | 0.655 |
Room air, n (%) | 507 (81.8) | 31 (88.6) | 145 (86.3) | 133 (81.1) | 95 (76.0) | 75 (79.8) | 28 (82.4) | 0.260 |
Nasal cannula, n (%) | 529 (85.3) | 32 (91.4) | 150 (89.3) | 141 (86.0) | 103 (82.4) | 75 (79.8) | 28 (82.4) | 0.252 |
Mask, n (%) | 411 (66.3) | 25 (71.4) | 119 (70.8) | 105 (64.0) | 79 (63.2) | 60 (63.8) | 23 (67.6) | 0.676 |
Continuous positive airway pressure (CPAP), n (%) | 78 (12.6) | 6 (17.1) | 22 (13.1) | 23 (14.0) | 13 (10.4) | 12 (12.8) | 2 (5.9) | 0.709 |
Bi-level positive airway pressure (BIPAP), n (%) | 87 (14.0) | 4 (11.4) | 24 (14.3) | 16 (9.8) | 20 (16.0) | 17 (18.1) | 6 (17.6) | 0.448 |
High-flow nasal cannula, n (%) | 296 (47.7) | 10 (28.6) | 56 (33.3) | 86 (52.4) | 76 (60.8) | 50 (53.2) | 18 (52.9) | < 0.001 |
Invasive mechanical ventilation, n (%) | 371 (59.8) | 23 (65.7) | 131 (78.0) | 98 (59.8) | 65 (52.0) | 40 (42.6) | 14 (41.2) | < 0.001 |
Prone ventilation, n (%) | 356 (57.4) | 16 (45.7) | 97 (57.7) | 97 (59.1) | 87 (69.6) | 47 (50.0) | 12 (35.3) | 0.002 |
Duration of invasive mechanical ventilation (days), median (IQR) | 9.1 (4.7–14.4) | 8.6 (3.5–17.0) | 9.9 (7.0–15.4) | 7.4 (4.1–12.1) | 8.9 (3.9–15.9) | 8.7 (4.0–15.7) | 3.9 (2.5–9.6) | 0.018 |
ICU length of stay (LOS) (days), median (IQR) | 6.2 (2.7–12.5) | 4.8 (3.4–13.7) | 9.1 (3.5–13.6) | 6.0 (2.5–11.4) | 6.2 (2.3–14.1) | 5.0 (2.6–9.1) | 4.0 (1.5–7.4) | 0.004 |
Hospital LOS (days), median (IQR) | 12.7 (7.5–21.8) | 10.7 (7.1–28.4) | 14.1 (8.1–23.0) | 13.6 (8.3–22.1) | 13.4 (7.2–21.6) | 10.0 (5.9–17.02) | 8.7 (5.5–16.1) | 0.009 |