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Table 1 Baseline characteristics and values of markers of lung injury in survivor versus non-survivors

From: Markers of endothelial and epithelial pulmonary injury in mechanically ventilated COVID-19 ICU patients

Variables Survivors (n = 20) Non-survivors (n = 11) p value
Age, years 61 ± 6 68 ± 6 0.05
Male, sex, no. % 17 (85) 9 (82) 0.59
BMI, Kg/m2 27.8 ± 4.1 28.9 ± 3.2 0.41
SAPS II at ICU admission 27 [21–38] 31 [21–37] 0.55
SOFA score at ICU admission 4 [2–5] 5 [3–6] 0.23
Length of ICU stay (days) 31 [25–43] 24 [16–31] 0.04
Comorbidities    
Hypertension, no. (%) 9 (45) 8 (73) 0.13
Dyslipidemia, no. (%) 4 (20) 1 (9) 0.40
Former smoker, no. (%) 4 (20) 6 (54) 0.06
Diabetes, no. (%) 4 (20) 1 (9) 0.40
COPD, no. (%) 2 (5) 2 (18) 0.45
Chronic kidney disease, no. (%) 3 (15) 5 (45) 0.08
Laboratory data at inclusion    
White blood cells, × 103/L 9.8 [7.5–12.9] 10.2 [8.8–12.7] 0.85
Lymphocytes, × 103/L 965 [640–1167] 680 [560–980] 0.18
Hemoglobin, g/dL 12.1 ± 1.8 13.1 ± 1.1 0.11
Platelets count, × 103/L 286 [265–386] 286 [195–332] 0.43
apTT, seconds 39 ± 5 37 ± 5 0.34
INR 1.1 ± 0.1 1.1 ± 0.1 0.35
Fibrinogen mg/dL 708 [655–888] 786 [532–862] 0.87
D-dimer, mcg/mL 31 [14–42] 36 [19–57] 0.31
IL-6, pg/mL 84 [17–149] 60 [37–145] 0.73
Respiratory variables at admission    
PaO2/ FiO2 ratio 183 [124–264] 116 [81–184] 0.045
PaCO2, mmHg 48 [36–56] 48 [41–69] 0.40
VT/PDW, mL 6.0 ± 0.5 6.0 ± 0.5 0.96
Driving Pressure, cmH2O 9 [8–11] 8 [7–14] 0.79
Compliance Respiratory System 57 [36–78] 60 [51–64] 0.95
Plateau pressure, cmH2O 18 [15–21] 21 [18–23] 0.11
PEEP setting (cmH2O) 12 [9–12] 10 [8–11] 0.07
  1. Data are reported as number (percentage), mean ± standard deviation or median [interquartile range] as appropriate. BMI: body mass index. COPD: chronic obstructive disease. P value: for the comparison between survivors vs non-survivors cases
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