Skip to main content

Table 4 Association of antibiotic therapy with outcomes in patients with VA-LRTI

From: Airway Pseudomonas aeruginosa density in mechanically ventilated patients: clinical impact and relation to therapeutic efficacy of antibiotics

VAT

Before propensity scores matching

After propensity scores matching

IAAT

AAT

P value

IAAT

AAT

P value

Low PA

 No. of patients

33

26

 

22

22

 

 VFDs at 28 days, median (IQR)

24 (0–27)

22 (14–25)

0.37

24 (0–26)

23 (12–25)

0.85

 ICU mortality

1 (3%)

3 (11.5%)

0.2

1 (4.6%)

3 (13.6%)

0.61

Moderate PA

 No. of patients

49

47

 

35

35

 

 VFDs at 28 days, median (IQR)

22 (0–27)

21 (0–25)

0.44

23 (0–27)

21 (0–25)

0.38

 ICU mortality

3 (6.1%)

9 (19.2%)

0.054

2 (5.7%)

6 (17.1%)

0.26

High PA

 No. of patients

33

48

 

25

25

 

 VFDs at 28 days, median (IQR)

0 (0–20)

19 (0–24)

0.02

0 (0–22)

17 (0–22)

0.06

 ICU mortality

9 (27.3%)

8 (16.7%)

0.25

9 (36%)

6 (24%)

0.54

VAP

IAAT

AAT

P value

Low PA

 No. of patients

11

5

 

 VFDs at 28 days, median (IQR)

13 (0–22)

9 (5–19)

1

ICU mortality

5 (45.5%)

0

0.07

Moderate PA

 No. of patients

13

6

 

 VFDs at 28 days, median (IQR)

0 (0–19)

0 (0–23)

0.8

 ICU mortality

6 (46.2%)

1 (16.7%)

0.22

High PA

 No. of patients

23

12

 

 VFDs at 28 days, median (IQR)

0 (0–0)

0 (0–13)

0.41

 ICU mortality

11 (47.8%)

5 (41.7%)

0.73

  1. AAT appropriate antibiotic therapy, IAAT inappropriate antibiotic therapy, ICU intensive care unit, IQR interquartile range, PA Pseudomonas aeruginosa, VFDs ventilator-free days, VA-LRTI ventilator-associated lower respiratory tract infection, VAP ventilator-associated pneumonia, VAT ventilator-associated tracheobronchitis