Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients

Table 2 Correlations between laboratory parameters and the plasma levels of cfDNA, MPO-DNA, C3 and C5 in COVID-19 patients

Parameter	cfDNA		MPO-DNA		C3		C5
Parameter	R	P	R	P	R	P	R	P
Immunological parameters^a
WBC (× 10⁹/L)	0.367	< 0.001	0.183	0.036	0.190	0.037	0.102	0.265
Neutrophil (× 10⁹/L)	0.439	< 0.001	0.305	0.001	0.318	0.001	0.129	0.159
CRP (U/L)	0.374	< 0.001	0.065	0.515	0.194	0.040	0.205	0.029
Coagulation parameters^b
D-dimer (g/L)	0.347	0.007	0.2442	0.043	0.240	0.024	0.139	0.196
PT (s)	0.615	< 0.001	0.073	0.484	− 0.0043	0.686	0.139	0.190
FDP (μg/mL)	0.474	< 0.001	0.316	0.002	0.300	0.005	0.068	0.526
PTA (%)	− 0.585	< 0.001	− 0.0725	0.4851	0.041	0.704	− 0.148	0.164
INR	0.588	< 0.001	0.073	0.480	− 0.042	0.695	0.144	-.175
Tissue damage parameters^a
LDH (U/L)	0.379	< 0.001	0.306	0.003	0.162	0.100	0.143	0.149
DBIL (µmol/L)	0.496	< 0.001	0.009	0.367	0.303	0.004	− 0.034	0.755
TBIL (µmol/L)	0.360	< 0.001	0.054	0.599	0.304	0.005	− 0.072	0.507
CK(U/L)	0.309	< 0.001	0.308	0.004	0.074	0.506	− 0.104	0.349
GFR (g/L)	− 0.389	< 0.001	− 0.187	0.165	− 0.333	0.002	− 0.129	0.236

Correlations were calculated by Spearman correlation analysis (r). a, the immunological parameters and tissue damage parameters were analyzed in all enrolled patients (n = 135); b, coagulation parameters were measured in 60 patients according to the needs of clinical examination. Mild, n = 19; Severe, n = 41. Abbreviations: WBC, white blood cells; CRP, C-reactive protein; PT, thrombin time; FDP, fibrin(-ogen) degradation products; PTA, prothrombin activity; INR, international normalized ratio; LDH, lactate dehydrogenase; DBIL, direct bilirubin; TBIL, total bilirubin; CK, creatine kinase; GFR, glomerular filtration rate
P < 0.05 was considered statistically significant and is shown in bold

ISSN: 1364-8535