Clinical parameters: | Mean arterial pressure, heart rate, respiratory rate, oxygen saturation, body temperature (every hour), intraabdominal pressure (2 × during the study), ventilator setting |
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Laboratory parameters: | Arterial lactate, hemoglobin, creatinine, bilirubin, albumin, CRP, INR at 5:00, glycemia at 6:00, 9:00, 12:00 |
HRM resting parameters | Tonus of LESa Inspiratory EGJ pressure (EGJP-insp). Average maximal inspiratory EGJ pressure for three respiratory cyclesa Expiratory EGJ pressure (EGJP-exp). Average EGJ pressure midway between inspirations for the same three respiratory cyclesa Esophagogastric junction contractile integral (EGJ-CI)a |
HRM dynamic parameters | Number of dry swallows and panesophageal secondary peristalsis/1 h Distal contractile integral (DCI) % of failed peristalsis % of panesophageal pressurizations % of premature contractions % of double-peaked waves Integrated relaxation time (IRP) Intrabolus pressure (IBP) |
Impedance | Number of liquid, mixed, and gaseous reflux episodes (defined as a sequential oral progressive decrease/increase in impedance below/above 40% baseline values distally with a retrograde propagation by at least 2 additional proximal observed fields in the absence of explanatory peristaltic component (median/hour of study) Number of distal and proximal refluxes Origin mechanism for each reflux episode: Swallow associated reflux (reflux within 10 s of finished swallow) Panesophageal secondary peristalsis associated reflux (reflux having TLESR character occurring within 10 s after panesophageal secondary peristalsis) Partial esophageal secondary peristalsis associated reflux (reflux having TLESR character occurring within 10 s after the non-swallowing partial esophageal activity) TLESR—reflux associated with a temporary decrease in LES tone below 5 mmHg, without association with dry swallow, esophageal secondary peristalsis or cough) Cough associated reflux (reflux within 30 s of cough episode/MV interference) Absence of the LES tone (reflux at low LES tone below 5 mmHg, without an association with esophageal contraction or cough) Panesophageal secondary peristalsis, partial esophageal secondary peristalsis in the close post-refulx period (within 10s of reflux) Cough Agitation |