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Table 1 Patients’ characteristics on the day of CT scan

From: Computed tomography assessment of PEEP-induced alveolar recruitment in patients with severe COVID-19 pneumonia

Parameter All (N = 42) Non-recruiters (N = 32) Recruiters (N = 10) p
Age, median [IQR], years 63 [58–67] 64 [58–67] 65 [58–66] 0.782
Predicted body weight, median [IQR], kg 70 [61–73] 70 [61–71] 72 [70–75] 0.102
Body mass index, median [IQR], kg/m2 28 [25–31] 28 [25–31] 28 [26–29]  > 0.999
Male sex, N (%) 33 (78.6) 24 (75.0) 9 (90.0) 0.416
Time from symptoms onset, median [IQR], days 23 [13–28] 23 [13–29] 20 [17–25] 0.631
Time from first confirmed swab, median [IQR], days 15 [10–23] 17 [9–24] 13 [10–20] 0.738
Time from start of invasive ventilation, median [IQR], days 9 [4–13] 9 [4–14] 7 [3–11] 0.328
Comorbidities     
Hypertension, N (%) 24 (57.1) 18 (56.3) 6 (60.0)  > 0.999
Cardiovascular disease, N (%) 5 (11.9) 3 (9.4) 2 (20.0) 0.577
Smoker, N (%) 1 (2.4) 1 (3.1) 0 (0.0)  > 0.999
Former smoker, N (%) 5 (11.9) 5 (15.6) 0 (0.0) 0.315
Chronic kidney failure, N (%) 1 (2.4) 1 (3.1) 0 (0.0)  > 0.999
Diabetes, N (%) 5 (11.9) 5 (15.6) 0 (0.0) 0.315
Obesity, N (%) 11 (26.2) 8 (25.0) 3 (30.0)  > 0.999
Ventilator settings     
Tidal volume, median [IQR], ml/kg PBW 7.2 [6.3–7.9] 7.3 [6.3–8.0] 6.9 [6.2–7.6] 0.494
Respiratory rate, median [IQR], 1/min 19 [17–25] 18 [16–25] 22 [19–24] 0.273
PEEP, median [IQR], cmH2O 10 [8–12] 10 [8–12] 10 [8–13] 0.988
Plateau pressure, median [IQR], cmH2O 24 [21–28] 24 [22–28] 24 [20–27] 0.782
FiO2, median [IQR] 0.60 [0.50–0.70] 0.68 [0.60–0.70] 0.55 [0.50–0.65] 0.138
Respiratory system compliance, median [IQR], ml/cmH2O 36 [29–50] 35 [29 –50] 40 [35–45] 0.631
Blood gas analysis     
pH, median [IQR] 7.43 [7.36–7.48] 7.42 [7.35–7.47] 7.46 [7.43–7.49] 0.052
PaO2, median [IQR], mmHg 73 [64–91] 73 [65–92] 69 [64–86] 0.475
PaCO2, median [IQR], mmHg 48 [43–56] 51 [44–58] 41 [36–51] 0.052
PaO2/FiO2, median [IQR], mmHg 123 [100–160] 123 [98–155] 139 [103–205] 0.494
Lactate, median [IQR], mmol/L 1.1 [0.8–1.8] 1.2 [0.8–2.0] 1.1 [1.0–1.6] 0.782
Ventilatory ratio 1.8 [1.5–2.4] 2.0 [1.5–2.6] 1.8 [1.6–1.8] 0.494
Blood analyses     
D-dimer, median [IQR], ug/L 1647 [1048–4426] 1618 [938–4195] 1754 [1304–4426] 0.695
C reactive protein, median [IQR], mg/L 42 [17–108] 44 [19–110] 41 [17–60] 0.531
Procalcitonin, median [IQR], ug/L 0.21 [0.09–0.97] 0.25 [0.09–1.44] 0.21 [0.07–0.33] 0.423
Interleukin-6, median [IQR], ng/L 127 [55–387] 134 [55–339] 112 [16–453] 0.873
Creatinine, median [IQR], mg/dL 0.9 [0.7–1.7] 0.9 [0.6–1.7] 1.0 [0.7–1.5] 0.652
Hemodynamics     
Heart rate, median [IQR], 1/min 82 [70–100] 85 [72–103] 73 [68–90] 0.494
Mean arterial pressure, median [IQR], mmHg 82 [73–93] 83 [77–102] 80 [73–85] 0.551
Ventilator-associated pneumonia, N (%) 12 (28.6) 11 (34.3) 1 (10.0) 0.233
  1. Gas exchange and ventilator settings measured at the clinical PEEP level
  2. IQR interquartile range, PBW predicted body weight, PEEP positive end-expiratory pressure, ICU intensive care unit
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