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Table 2 Pre-filter cytokine concentrations at pre-determined time points

From: Clearance of inflammatory cytokines in patients with septic acute kidney injury during renal replacement therapy using the EMiC2 filter (Clic-AKI study)

Cytokines (pg/ml)

T0 (n = 12)

T1 (n = 12)

T6 (n = 12)

T24 (n = 11)

T48 (n = 7)

p value*

IL-2

2.68

(0,4.18)

1.21

(0, 2.73)

0

(0, 2.67)

0

(0, 3.32)

0

(0, 4.75)

< 0.001

IL-4

1.30

(1.17, 1.92)

1.4

(1.16, 2.03)

1.36

(1.15, 1.84)

1.19

(0.99, 2.24)

1.19

(0.99,1.94)

< 0.001

IL-6

311.03

(30.92, 1175.13)

84.22

(35.02, 1336.48)

80.64

(30.12, 1273.17)

27.48

(23.33, 548.69)

90.82

(14.4,153.54)

< 0.001

IL-8

83.21

(55.10, 588.14)

74.15

(21.79, 446.88)

88.83

(20.82, 356.09)

60.44

(22.65, 222.59)

37.28

(19.99, 77.22)

< 0.001

IL-10

9.35

(4.38, 25.46)

10.04

(4.35, 27.55)

9.03

(3.96, 19.89)

6.58

(3.32, 9.42)

4.95

(1.54, 6.93)

0.008

VEGF

41.25

(21.78, 64.97)

35.86

(10.46, 59.43)

29.00

(14.9, 35.68)

30.28

(20.77, 39.77)

28.64

(13.93, 38.23)

< 0.001

IFN-γ

1.59

(1.31, 1.92)

1.62

(0,2.76)

1.01

(0, 2.34)

0

(0, 1.89)

0

(0, 1.46)

< 0.001

TNF-α

5.84

(4.55, 18.03)

5.30

(3.2, 13.33)

4.63

(3.44, 13.83)

4.14

(2.85, 9.1)

4.08

(3.14, 4.61)

< 0.001

IL-1α

0.72

(0, 1.59)

0.24

(0, 1.27)

0

(0, 1.07)

0

(0, 1.29)

0.56

(0, 1.33)

< 0.001

IL-1β

1.37

(0.5, 2.79)

1.09

(0, 1.71)

1.19

(0, 1.77)

0

(0, 1.47)

0

(0, 1.64)

< 0.001

MCP-1

571.9

(335.2, 1436.69)

516.75

(311.89, 779.07)

457.74

(275.88, 646.24)

316.63

(201.93, 742.44)

262.63

(116.93, 451.12)

< 0.001

EGF

1.34

(0, 1.49)

0

(0, 1.66)

1.30

(0, 1.62)

1.38

(0, 1.68)

1.76

(0,1.84)

< 0.001

  1. Values expressed as median (interquartile range)
  2. Normal range from literature for baseline cytokine concentrations in sepsis (in pg/mL):
  3. IL-2 = 0 (0–108.5); IL-4 = 8.88 (93.2–202.7); IL-6 = 376–2375; TNF-α = 4.43 to 33; IL-8 = 215 to 1349; IL-1β = 0 to 66.02; IL-10 = 88.55 to 638; IFN-γ = 20.82 to 275 pg/mL; MCP-1 = 454.2 (97.4–22,000); EGF = 35.9 ± 58.03, VEGF = 27.58 to 1082, IL-1α = 0.12 to 0.36 pg/mL [25,26,27,28,29,30,31,32,33,34]
  4. IL interleukin, VEGF vascular endothelial growth factor, IFN interferon, TNF tumour necrosis factor, MCP monocyte chemoattractant protein, EGF epidermal growth factor
  5. *p value for differences in cytokine concentrations for all time points using generalized estimating equations (GEE)
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Critical Care

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