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Table 1 Baseline characteristics and demographics of human study 1 and human study 2

From: The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis

 

Human study 1

P value

Human study 2

P value

Patients n = 51

Controls n = 20

Patients n = 47

Controls n = 20

Gender—male, n (%)

33 (68%)

11 (55%)

.45

37 (79%)

14 (70%)

.44

Age—y, mean (SD)

60.0 ± 5.1

58.5 ± 15.8

.55

63.3 ± 13.7

64.1 ± 10.9

.80

BMIa—kg/m2, mean (SD)

26.1 ± 4.6

24.3 ± 3.0

.06

27.5 ± 5.8

26.6 ± 3.0

.40

Diabetes mellitus, n (%)

8 (16%)

  

8 (17%)

  

Malignancy, n (%)

14 (27%)

  

9 (19%)

  

APACHE II scoreb, mean (SD)

30.3 ± 8.2

  

32.0 ± 7.4

  

Urgent admission, n (%)

44 (86%)

  

41 (87%)

  

Sepsisc, n (%)

51 (100%)

  

47 (100%)

  

Septic shockc, n (%)

13 (25%)

  

38 (81%)

  
  1. aBody mass index (BMI) is calculated as the weight in kilograms divided by the square of the height in meters
  2. bAcute Physiology and Chronic Health Evaluation II (APACHE II) score reflects severity of illness, with higher values indicating more severe illness, and can range from 0 to 7 [33]
  3. cSepsis and septic shock were defined as in Ref. [16]