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Fig. 5 | Critical Care

Fig. 5

From: Angiopoietin-2 outperforms other endothelial biomarkers associated with severe acute kidney injury in patients with severe sepsis and respiratory failure

Fig. 5

Higher plasma angiopoietin-2 levels by quartile were significantly associated with a hepatic failure, b coagulation failure and c circulatory failure on enrollment day. Organ failures were defined by Brussels organ failure scores. d Plasma angiopoietin-2 levels were not associated with the development of ARDS defined by Berlin criteria during the study period. e Plasma angiopoietin-2 levels were associated with the number of organ failures on enrollment day. f Severe sepsis patients who died during hospitalization had significantly higher plasma angiopoietin-2 levels compared to those who survived. Groups in panels a–d were analyzed by linear-by linear association test. Data in panels e and f were summarized as boxplots where box encompassed 25‒75th percentile, error bars encompassed 10‒90th percentile and horizontal line showed median. Groups were compared by Kruskal–Wallis test (panel e) or Mann–Whitney U test (panel f). Post hoc analysis of groups comparison was performed using Mann–Whitney U test and Bonferroni correction (panel e)

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