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Table 1 Global hemodynamic and tissue perfusion parameters before and after (H24) Landiolol initiation

From: Rate control in atrial fibrillation using Landiolol is safe in critically ill Covid-19 patients

Patient characteristics n = 15
Age (years old) 70 [67–72]
Women, n (%) 4 (27)
SOFA 11 [7–12]
Left ventricular ejection fraction (LVEF) (%) 55 [50–57]
LVEF ≥ 60% (n) 4/15
LVEF ≥ 50% and < 60% (n) 8/15
LVEF ≥ 40% and < 50% (n) 3/15
Time between ICU admission and injection (days) 2 [0–5]
Comorbidities, n (%)
 Arterial hypertension 8 (53)
 Diabetes mellitus 4 (27)
 Vascular disease 5 (33)
Norepinephrine, n (%) 11 (73)
Mechanical ventilation, n (%) 15 (100)
Hemodynamic kinetics H0 H24 p
Global hemodynamics
 Heart rate (bpm) 150 [138–160] 115 [108–117] < 0.01
 Systolic blood pressure (mmHg) 115 [99–130] 120 [108–125] 0.70
 Diastolic blood pressure (mmHg) 58 [51–74] 60 [53–66] 0.71
 Mean arterial pressure (mmHg) 79 [69–89] 76 [72–88] 0.76
 Norepinephrine dose (µg/kg/min) 1 [0.4–1.5] 0.7 [0.2–1] 0.04
Tissue perfusion parameters
 Index capillary refill time (s) 2 [1.5–2.5] 2 [1.6–2.5] 0.75
 Mottling score n (%)    0.62
  0–1 12 (80) 13 (87)  
  2–3 1 (7) 2 (13)  
  > 4 2 (13) 0 (0)  
 Arterial lactate level (mmol/L) 3.2 [2–4.9] 2.2 [1.7–2.8] 0.05