Table 1 Global hemodynamic and tissue perfusion parameters before and after (H24) Landiolol initiation
From: Rate control in atrial fibrillation using Landiolol is safe in critically ill Covid-19 patients
Patient characteristics | n = 15 |
|---|---|
Age (years old) | 70 [67–72] |
Women, n (%) | 4 (27) |
SOFA | 11 [7–12] |
Left ventricular ejection fraction (LVEF) (%) | 55 [50–57] |
LVEF ≥ 60% (n) | 4/15 |
LVEF ≥ 50% and < 60% (n) | 8/15 |
LVEF ≥ 40% and < 50% (n) | 3/15 |
Time between ICU admission and injection (days) | 2 [0–5] |
Comorbidities, n (%) | |
Arterial hypertension | 8 (53) |
Diabetes mellitus | 4 (27) |
Vascular disease | 5 (33) |
Norepinephrine, n (%) | 11 (73) |
Mechanical ventilation, n (%) | 15 (100) |
Hemodynamic kinetics | H0 | H24 | p |
|---|---|---|---|
Global hemodynamics | |||
Heart rate (bpm) | 150 [138–160] | 115 [108–117] | < 0.01 |
Systolic blood pressure (mmHg) | 115 [99–130] | 120 [108–125] | 0.70 |
Diastolic blood pressure (mmHg) | 58 [51–74] | 60 [53–66] | 0.71 |
Mean arterial pressure (mmHg) | 79 [69–89] | 76 [72–88] | 0.76 |
Norepinephrine dose (µg/kg/min) | 1 [0.4–1.5] | 0.7 [0.2–1] | 0.04 |
Tissue perfusion parameters | |||
Index capillary refill time (s) | 2 [1.5–2.5] | 2 [1.6–2.5] | 0.75 |
Mottling score n (%) | 0.62 | ||
0–1 | 12 (80) | 13 (87) | |
2–3 | 1 (7) | 2 (13) | |
> 4 | 2 (13) | 0 (0) | |
Arterial lactate level (mmol/L) | 3.2 [2–4.9] | 2.2 [1.7–2.8] | 0.05 |