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Table 2 Illness severity in study subpopulation with no treatment limitations at ICU discharge stratified by vital status at hospital discharge

From: Death in hospital following ICU discharge: insights from the LUNG SAFE study

Parameter

Alive N = 2186

Dead N = 142

Total N = 2328

p value

Illness severity at 1st day of AHRF

ARDS, n (%)

1,242 (56.82)

76 (53.52)

1,318 (56.62)

0.4427

Gas exchange

 PaO2/FiO2 (mmHg), mean ± SD

173.81 ± 66.30

182.49 ± 63.28

174.34 ± 66.14

0.1032

 SpO2 (%), median [IQR]

96.0 [94.0–98.0]

96.0 [94.0–98.0]

96.0 [94.0–98.0]

0.7613

 PaCO2 (mmHg), mean ± SD

45.34 ± 14.88

44.80 ± 14.40

45.31 ± 14.85

0.8351

 pH, mean ± SD

7.35 ± 0.10

7.35 ± 0.10

7.35 ± 0.10

0.9699

Adjusted SOFA scores, mean ± SD

8.33 ± 3.72

9.30 ± 3.58

8.39 ± 3.72

0.0010

Illness severity at last available day in ICU

ARDS, n (%)

132 (7.65)

8 (7.14)

140 (7.62)

0.8452

Gas exchange

 PaO2/FiO2 (mmHg)

  Mean ± SD

259.00 ± 91.83

252.83 ± 86.61

258.58 ± 91.47

0.7798

  Available data, n (%)

1163 (53.20)

85 (59.86)

1248 (53.61)

0.1232

 SpO2 (%)

  Median [IQR]

97.0 [95.0–98.0]

97.0 [95.0–99.0]

97.0 [95.0–98.0]

0.7263

  Available data, n (%)

1381 (63.17)

89 (62.68)

1470 (63.14)

0.9050

 PaCO2 (mmHg)

  Mean ± SD

42.40 ± 10.97

42.01 ± 11.49

42.38 ± 10.99

0.6008

  Available data, n (%)

1265 (57.87)

90 (63.38)

1355 (58.20)

0.1969

 pH (unit)

  Mean ± SD

7.43 ± 0.05

7.43 ± 0.06

7.43 ± 0.06

0.4129

  Available data, n (%)

1271 (58.14)

90 (63.38)

1361 (58.46)

0.2197

Adjusted non-pulmonary SOFA scores, mean ± SD

 Mean ± SD

2.49 ± 2.75

4.08 ± 3.37

2.59 ± 2.82

< .0001

 Available data, n (%)

1337 (61.16)

97 (68.31)

1434 (61.60)

0.0897

Adjusted SOFA scores, mean ± SD

 Mean ± SD

3.87 ± 3.16

5.62 ± 3.71

3.99 ± 3.60

< .0001

 Available data, n (%)

1341(61.34)

97 (68.31)

1438 (61.77)

0.0979

  1. ARDS acute respiratory distress syndrome, FiO2 fraction of inspired oxygen, IBW ideal body weight, ICU intensive care unit, IQR interquartile range [first and third quartile], PaCO2 partial pressure arterial carbon dioxide, PaO2 partial pressure arterial oxygen, PEEP positive end-expiratory pressure, PIP peak inspiratory pressure, SD standard deviation, SOFA sequential organ failure assessment.