Table 3 Performance of NfL at different cut-off points to predict neurological Outcome

Poor outcome/total per group

12/43

15/38

71/83

16/43

21/38

74/83

8/43

15/38

68/83

Sensitivity Pr(+ A)

87.80%

72.40%

61.20%

85.60%

66.70%

55.00%

91.20%

74.70%

63.70%

Specificity Pr(− N)

47.00%

81.80%

90.90%

50.90%

83.00%

90.60%

47.90%

79.50%

89.00%

ROC area (sens. + spec.)/2

0.67

0.77

0.76

0.68

0.75

0.73

0.7

0.77

0.76

Likelihood ratio ( +) Pr(+ A)/Pr(+ N)

1.65

3.98

6.73

1.74

3.93

5.83

1.75

3.64

5.82

Likelihood ratio (−)

Pr(− A)/Pr(− N)

0.26

0.34

0.43

0.28

0.4

0.5

0.18

0.32

0.41

Odds ratio LR( +)/LR(−)

6.35

11.83

15.79

6.17

9.78

11.71

9.56

11.43

14.28

Positive predictive value Pr(A +)

71.10%

85.50%

90.90%

78.50%

89.20%

92.40%

68.60%

81.90%

87.90%

Negative predictive value

Pr(N −)

72.10%

66.70%

61.20%

62.80%

54.30%

49.00%

81.40%

71.60%

66.30%