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Table 1 Baseline characteristics

From: Serum neurofilament measurement improves clinical risk scores for outcome prediction after cardiac arrest: results of a prospective study

Factor

CPC All

Good neurological outcome, CPC 1–2

Poor neurological outcome, CPC 3–5

p value

N, n (%)

164 (100%)

66 (40%)

98 (60%)

 

Sociodemographics

Age, mean (SD)

63 (15)

60 (17)

65 (14)

0.027

Male, n (%)

117 (71.3%)

55 (83%)

62 (63%)

0.008

Comorbidities

Coronary heart disease, n (%)

109 (66.5%)

50 (76%)

59 (60%)

0.044

Congestive heart failure, n (%)

20 (12.2%)

7 (11%)

13 (13%)

0.81

COPD, n (%)

15 (9.1%)

3 (5%)

12 (12%)

0.11

Liver disease, n (%)

3 (1.8%)

0 (0%)

3 (3%)

0.27

Hypertension, n (%)

86 (52.4%)

37 (56%)

49 (50%)

0.52

Diabetes, n (%)

39 (23.8%)

9 (14%)

30 (31%)

0.015

Chronic kidney disease, n (%)

24 (14.6%)

8 (12%)

16 (16%)

0.51

Malignant disease, n (%)

14 (8.5%)

2 (3%)

12 (12%)

0.047

Neurological disease, n (%)

13 (7.9%)

2 (3%)

11 (11%)

0.077

Resuscitation measures

No-flow time, min, mean (SD)

4.22 (5.93)

1.70 (2.96)

6.02 (6.83)

 < 0.001

Low-flow time, min, mean (SD)

20.42 (15.13)

16.53 (14.30)

23.12 (15.17)

0.006

Cardiac arrest setting

At home

63 (38.4%)

16 (24%)

47 (48%)

 < 0.001

In public

78 (47.6%)

43 (65%)

35 (36%)

In hospital

23 (14.0%)

7 (11%)

16 (16%)

Witnessed

137 (83.5%)

63 (95%)

74 (76%)

 < 0.001

Bystander CPR

103 (62.8%)

51 (77%)

52 (53%)

0.002

Initial heart rhythm

Ventricular tachycardia

6 (3.7%)

2 (3%)

4 (4%)

 < 0.001

Ventricular fibrillation

88 (53.7%)

53 (80%)

35 (36%)

Asystole

35 (21.3%)

2 (3%)

33 (34%)

Pulseless electrical activity

29 (17.7%)

6 (9%)

23 (23%)

Unknown

6 (3.7%)

3 (5%)

3 (3%)

Epinephrine during resuscitation (mg), mean (SD)

2.18 (2.55)

1.08 (1.76)

2.96 (2.73)

 < 0.001

Targeted temperature management (TTM), n (%)

109 (66.5%)

40 (61%)

69 (70%)

0.19

Initial clinical parameter and levels of routine blood markers

GCS, mean (SD)

7.3 (4.1)

7 (5)

4 (1)

 < 0.001

pH, mean (SD)

7.25 (0.12)

7.29 (0.09)

7.22 (0.13)

0.003

Lactate, mean (SD)

7.3 (4.1)

5.9 (3.3)

8.3 (4.2)

 < 0.001

NfL (pg/ml), mean (SD)

429 (1415)

49 (111)

685 (1787)

0.004

NfL (pg/ml), median (IQR)

51 (21, 173)

27 (13, 46)

116 (41, 330)

 < 0.001

  1. Data presented as n (%) or mean (standard deviation) and median (Inter Quartile Range, IQR). COPD, chronic obstructive pulmonary disease; CPR, cardiopulmonary resuscitation; NfL, Neurofilament Light Chain; GCS, Glasgow Coma Scale; Neurological disease includes cerebrovascular diseases (e.g., stroke, brain haemorrhage), degenerative diseases such as multiple sclerosis or Parkinson’s disease and peripheral neurological disease