Table 1 Baseline characteristics and management of the study population (n = 1943) according to the estimated glomerular filtration rate calculated with the four-variable Modification of Diet in Renal Disease (eGFRMDRD4) formula
Variables | Total (n = 1943) | eGFRMDRD4 < 60 ml/min | p value | |
|---|---|---|---|---|
Yes (n = 477) | No (n = 1466) | |||
Age, years | 67.3 ± 17.1 | 77.3 ± 11.9 | 64.1 ± 17.3 | < 0.001 |
Male (%) | 962 (45.5) | 182 (38.2) | 780 (53.2) | < 0.001 |
BMI (kg/m2) | 27.4 ± 5.5 | 28.0 ± 6.2 | 27.1 ± 5.8 | 0.007 |
Site of care | ||||
Conventional ward | 1328 (68.3) | 251 (52.6) | 1077 (73.4) | – |
Intensive care unit | 615 (31.6%) | 226 (47.3) | 389 (26.5) | – |
Comorbidities (%) | ||||
Coronary disease | 282 (14.5) | 109 (22.8) | 173 (11.8) | < 0.001 |
Pulmonary disease/HF | 174 (8.5) | 54 (11.3) | 120 (8.2) | 0.03 |
Active cancer | 367 (18.9) | 84 (17.6) | 283 (19.3) | 0.41 |
Prior VTE | 474 (24.3) | 115 (24.1) | 359 (24.5) | 0.86 |
Prior bleeding | 67 (3.4) | 26 (3.5) | 41 (3.4) | 0.87 |
Low risk for long-term VTE recurrence (%) | 486 (25.0) | 113 (23.7) | 373 (25.4) | 0.44 |
Associated DVT (%) | 794 (40.8) | 195 (40.9) | 599 (40.8) | 0.99 |
Clinical characteristics | ||||
HR at admission (bpm) | 89.6 ± 19.3 | 89.7 ± 19.5 | 89.6 ± 19.2 | 0.92 |
SBP at admission (mmHg) | 137.1 ± 22.3 | 135.5 ± 26.2 | 138 ± 21.9 | 0.03 |
SaO2 (%) | 93.4 ± 23.7 | 92.9 ± 5.4 | 93.9 ± 4.9 | < 0.001 |
Biological data | ||||
Hemoglobin (g/dL) | 13.2 ± 2.6 | 12.8 ± 2.27 | 13.5 ± 3.4 | < 0.001 |
Positive troponin | 853 (43.9) | 308 (564.6) | 545 (37.2) | < 0.001 |
Echo data | ||||
sPAP (mmHg) | 42.7 ± 15.8 | 47.9 ± 15.7 | 40.6 ± 15.3 | < 0.001 |
RV dysfunctiona | 800 (41.2) | 258 (54.1) | 542 (36.9) | < 0.001 |
Peak systolic gradient at the tricuspid valve > 30 mmHg | 639 (32.9) | 218 (45.7) | 421 (28.7) | < 0.001 |
End-diastolic RV/LV diameter ≥ 1.0 in the apical four-chamber view | 291 (15.0) | 112 (23.5) | 179 (12.2) | < 0.001 |
Flattened intraventricular septum | 267 (13.7) | 99 (20.7) | 168 (11.5) | < 0.001 |
TAPSE < 16 mm | 85 (4.4) | 33 (6.9) | 52 (3.5) | 0.002 |
Right heart thrombus | 26 (1.3) | 11 (2.3) | 15 (1.0) | 0.03 |
sPESI (points, Q1-Q3) | 1 (1–2) | 2 (1–3) | 1 (0–2) | < 0.001 |
In-hospital treatments (%) | ||||
Reperfusion therapy | ||||
Thrombolysis | 93 (4.8) | 43 (9.0) | 50 (3.4) | < 0.001 |
Surgical embolectomy | 9 (0.5) | 5 (1.0) | 4 (0.3) | 0.03 |
ECMO | 9 (0.5) | 7 (1.5) | 2 (0.1) | < 0.001 |
Inferior vena cava filter | 8 (0.4) | 3 (0.6) | 5 (0.3) | 0.39 |
Outpatient treatmentb | 28 (1.4) | 7 (1.4) | 21 (1.4) | 1.0 |
Early dischargec | 198 (10.2) | 38 (8.0) | 160 (10.9 | 0.07 |