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Table 2 Factors associated with day 1 hyperoxemia (PaO2 > 100 mmHg) and with excess oxygen use (FIO2 ≥ 0.6 in patients with PaO2 > 100 mmHg) in the study population

From: Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study

Parameter

Odds ratio (95% confidence interval)

p value

Outcome—hyperoxemia at day 1 (model* on 1855 patients)

 FIO2 (0.1 unit)

1.168 (1.115; 1.224)

< .0001

 Bicarbonate (mmol/L)

0.967 (0.951; 0.984)

< .0001

 Total respiratory rate (breath/min)

0.971 (0.956; 0.986)

0.0002

 PEEP (cmH2O)

0.944 (0.910; 0.979)

0.0017

 Active/hematologic neoplasm or immunosuppression (ref. no.)

1.414 (1.111; 1.801)

0.0050

 SOFA score – Cardiovascular

0.925 (0.870; 0.984)

0.0139

 Heart failure (ref. no.)

1.482 (1.080; 2.033)

0.0148

Outcome—excess oxygen use at day 1 (model°on 1694 patients)

 PaO2/FIO2 (mmHg)

0.978 (0.976; 0.980)

< .0001

 PEEP (cmH2O)

1.144 (1.091; 1.199)

< .0001

 PIP (cmH2O)

1.029 (1.014; 1.045)

0.0002

 Bicarbonate (mmol/L)

0.971 (0.954; 0.989)

0.0013

 Age (years)

0.988 (0.981; 0.996)

0.0023

 BMI (kg/m2)

0.980 (0.965; 0.995)

0.0111

 Tidal volume (ml/kg IBW)

1.081 (1.017; 1.149)

0.0122

  1. Abbreviations: BMI body mass index, FIO2 fraction of inspired oxygen, PEEP positive end-expiratory pressure, PIP peak inspiratory pressure, SOFA sepsis-related organ failure, PaO2 arterial oxygen partial pressure, IBW ideal body weight
  2. *Multivariable logistic model with presence of hyperoxemia (PaO2 > 100 mmHg) as dependent dichotomous variable and the predictors were identified by stepwise approach. One hundred and fifty patients were excluded due to missing values for the response or explanatory variables. List of possible predictors in stepwise approach: age, sex, body mass index, comorbidities (presence of heart failure, diabetes mellitus chronic renal failure, chronic obstructive pulmonary disease or home ventilation, active neoplasm of hematologic neoplasm or immunosuppression), ARDS risk factors (none, only non-pulmonary, only pulmonary, both types), bicarbonates concentration, management factors (presence of invasive mechanical ventilation, tidal volume, PEEP, PIP, total respiratory rate, minute ventilation), and FIO2 and SOFA components (CNS, cardiovascular, renal, liver, coagulation score)
  3. °Multivariable logistic model with excess of oxygen use (FIO2 ≥ 0.6 and PaO2 > 100 mmHg) as dependent dichotomous variable and predictors identified by stepwise approach. Three hundred and eleven observations were deleted due to missing values for the response or explanatory variables
  4. List of possible predictors in stepwise approach: age, sex, body mass index, comorbidities (presence of heart failure, diabetes mellitus chronic renal failure, chronic obstructive pulmonary disease or home ventilation, active neoplasm of hematologic neoplasm or immunosuppression), ARDS risk factors (none, only non-pulmonary, only pulmonary, both types), bicarbonates concentration, management factors (presence of invasive mechanical ventilation, tidal volume, PEEP, PIP, total respiratory rate, minute ventilation), and PaO2/FIO2 ratio and non-respiratory SOFA components (CNS, cardiovascular, renal, liver, coagulation score)
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Critical Care

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