Renal replacement therapy is independently associated with a lower risk of death in patients with severe acute kidney injury treated with targeted temperature management after out-of-hospital cardiac arrest

Table 3 Factors associated with 6-month mortality in patients who developed stage 3 acute kidney injury after an out-of-hospital cardiac arrest

Variable	Coefficient	Standard error	Wald	P value	Hazards ratio	95% CI
Age	0.004	0.008	0.271	0.60	1.004	0.989–1.019
Male gender	− 0.033	0.221	0.022	0.88	0.967	0.628–1.491
Body weight	0.021	0.008	7.210	0.01	1.021	1.006–1.037
Hypertension	− 0.087	0.213	0.166	0.68	0.917	0.604–1.391
Heart failure	− 1.106	0.569	3.774	0.05	0.331	0.108–1.010
Diabetes mellitus	− 0.078	0.229	0.117	0.73	0.925	0.590–1.448
Arrest location				0.05
Witnessed arrest	− 0.299	0.233	1.654	0.20	0.741	0.470–1.170
Bystander CPR	− 0.219	0.268	0.669	0.41	0.803	0.475–1.359
Time from collapse to CPR	0.002	0.019	0.015	0.90	1.002	0.965–1.041
Time from CPR to ROSC	− 0.004	0.006	0.342	0.56	0.996	0.984–1.009
Epinephrine, mg	0.043	0.026	2.807	0.09	1.044	0.993–1.098
Initial rhythm				0.42
Arrest cause				0.56
Lactate after ROSC	0.034	0.022	2.535	0.11	1.035	0.992–1.080
Shock after ROSC	0.252	0.374	0.453	0.50	1.286	0.618–2.676
TT of 36 °C	− 0.222	0.250	0.789	0.37	0.801	0.490–1.308
TTM duration of 48 h	0.461	0.714	0.417	0.52	1.586	0.392–6.421
^† Seizure	− 0.472	0.251	3.526	0.06	0.624	0.381–1.021
^† Bleeding	0.333	0.364	0.838	0.36	1.395	0.684–2.845
^† Sepsis	0.264	0.228	1.351	0.25	1.303	0.834–2.035
^† Hypoglycaemia	0.462	0.230	4.038	0.04	1.587	1.011–2.489
^† Sustained hyperglycaemia	0.257	0.206	1.561	0.21	1.294	0.864–1.937
^† Tachycardia	− 0.236	0.235	1.013	0.31	0.790	0.498–1.251
^† Bradycardia	0.069	0.684	0.010	0.92	1.071	0.281–4.089
^† Re-arrest	0.767	0.238	10.354	0.001	2.152	1.349–3.433
RRT	− 0.565	0.209	7.289	0.01	0.569	0.377–0.857

P < 0.05 are presented in bold
CPR cardiopulmonary resuscitation, ROSC return of spontaneous circulation, RRT renal replacement therapy, TT target temperature, TTM targeted temperature management
^†Event recorded within 7 days since return of spontaneous circulation

ISSN: 1364-8535