# Table 3 Associations between fluid time and VIS by hour using univariate and multivariable GEE linear regression models

Variables

Univariate analysisâ€

Multivariable analysisâ€¡

Mean estimate (95% CI)

P value

Mean estimate (95% CI)

P value

Fluid replacement rate; ml/kg/min

Â

<â€‰.001

Â

<â€‰.001

â€ƒâ‰¥â€‰0.5

0.00 (ref)

Â

0.00 (ref)

Â

â€ƒ0.25â€“0.49

0.18 (âˆ’â€‰1.89, 2.24)

Â

0.11 (âˆ’â€‰1.77, 2.00)

Â

â€ƒ0.17â€“0.24

âˆ’â€‰0.03 (âˆ’â€‰2.34, 2.28)

Â

âˆ’â€‰0.15 (âˆ’â€‰2.23, 1.92)

Â

â€ƒ<â€‰0.17

âˆ’â€‰2.62 (âˆ’â€‰4.08, âˆ’â€‰1.16)

Â

âˆ’â€‰2.41 (âˆ’â€‰3.79, âˆ’â€‰1.03)

Â

VIS time (per 1â€‰h)

0.20 (0.15, 0.24)

<â€‰.001

0.18 (0.13, 0.22)

<â€‰.001

Age (per year)

âˆ’â€‰0.01 (âˆ’â€‰0.05, 0.03)

.6

âˆ’â€‰0.03 (âˆ’â€‰0.08, 0.02)

.2

Male sex

âˆ’â€‰0.07 (âˆ’â€‰1.25, 1.11)

.9

0.33 (âˆ’â€‰0.74, 1.41)

.5

White race

âˆ’â€‰0.73 (âˆ’â€‰2.79, 1.34)

.5

âˆ’â€‰0.24 (âˆ’â€‰2.18, 1.70)

.8

Weight (per 10â€‰kg)

âˆ’â€‰0.5 (âˆ’â€‰0.7, âˆ’â€‰0.4)

<â€‰.001

âˆ’â€‰0.5 (âˆ’â€‰0.7, âˆ’â€‰0.3)

<â€‰.001

Charlson comorbidity index

0.02 (âˆ’â€‰0.19, 0.23)

.9

0.04 (âˆ’â€‰0.18, 0.27)

.7

APACHE III score

0.09 (0.07, 0.11)

<â€‰.001

0.05 (0.01, 0.08)

.007

SOFA

0.68 (0.52, 0.84)

<â€‰.001

0.41 (0.16, 0.66)

<â€‰.001

1. â€ Mean estimate and P value are adjusted only for the row covariate
2. â€¡Mean estimate and P value are adjusted for all covariates listed in the table