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Table 3 Associations between fluid time and VIS by hour using univariate and multivariable GEE linear regression models

From: Effect of initial infusion rates of fluid resuscitation on outcomes in patients with septic shock: a historical cohort study

VariablesUnivariate analysisMultivariable analysis
Mean estimate (95% CI)P valueMean estimate (95% CI)P value
Fluid replacement rate; ml/kg/min < .001 < .001
 ≥ 0.50.00 (ref) 0.00 (ref) 
 0.25–0.490.18 (− 1.89, 2.24) 0.11 (− 1.77, 2.00) 
 0.17–0.24− 0.03 (− 2.34, 2.28) − 0.15 (− 2.23, 1.92) 
 < 0.17− 2.62 (− 4.08, − 1.16) − 2.41 (− 3.79, − 1.03) 
VIS time (per 1 h)0.20 (0.15, 0.24)< .0010.18 (0.13, 0.22)< .001
Age (per year)− 0.01 (− 0.05, 0.03).6− 0.03 (− 0.08, 0.02).2
Male sex− 0.07 (− 1.25, 1.11).90.33 (− 0.74, 1.41).5
White race− 0.73 (− 2.79, 1.34).5− 0.24 (− 2.18, 1.70).8
Weight (per 10 kg)− 0.5 (− 0.7, − 0.4)< .001− 0.5 (− 0.7, − 0.3)< .001
Charlson comorbidity index0.02 (− 0.19, 0.23).90.04 (− 0.18, 0.27).7
APACHE III score0.09 (0.07, 0.11)< .0010.05 (0.01, 0.08).007
SOFA0.68 (0.52, 0.84)< .0010.41 (0.16, 0.66)< .001
  1. Mean estimate and P value are adjusted only for the row covariate
  2. Mean estimate and P value are adjusted for all covariates listed in the table