Role of ICU-acquired weakness on extubation outcome among patients at high risk of reintubation

Table 2 Multivariate logistic regression analysis of factors associated with extubation failure defined as reintubation or death within the first 7 days following extubation

Variables	Adjusted odds ratio* [95% confidence interval]	p value
Model A entering MRC sum-score as continuous variable (R² = 0.079)
SAPS II at admission—for each point increase	1.02 [1.01–1.04]	0.0233
Ineffective cough	2.72 [1.11–6.62]	0.0281
MRC sum-score—for each point lost	1.03 [1.01–1.05]	0.0067
Model B entering MRC according to MRC sum-score < 48 (ICU-acquired weakness) or ≥ 48 (reference) (R² = 0.069)
SAPS II at admission—for each point increase	1.02 [1.01–1.04]	0.0121
Ineffective cough	3.04 [1.27–7.29]	0.0127
ICU-acquired limb weakness (MRC sum-score < 48)	1.89 [1.02–3.48]	0.0426
Model C entering MRC according to moderate, severe or no weakness (MRC sum-score ≥ 48 as reference) (R² = 0.071)
SAPS II at admission—for each point increase	1.02 [1.01–1.04]	0.0164
Ineffective cough	2.90 [1.19–7.00]	0.0187
Moderate weakness (48 < MRC sum-score ≥ 36)	1.60 [0.74–3.47]	0.2342
Severe weakness (MRC sum-score < 36)	2.19 [1.06–4.54]	0.0351

All variables associated with extubation failure with a p value < 0.15 were included in the model (R² = 0.104, 1) SAPS II at admission (age was not included in the maximal model given this variable is already included in the SAPS II calculation), (2) duration of mechanical ventilation prior to extubation, (3) moderate and severe ICU-acquired limb weakness, (4) ineffective cough (vs. effective or moderate), (5) abundant secretions, and (6) use of prophylactic non-invasive ventilation after extubation
SAPS II Simplified Acute Physiological Score II, ICU intensive care unit, MRC Medical Research Council
*Values of adjusted odds ratio are from the final model including only variables independently associated with extubation failure

ISSN: 1364-8535