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Table 3 Risk factors for 30-day mortality (univariate and multivariate analysis)

From: Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts

VariableAll episodes, N = 317 (%)Alive, N = 247 (%)Died, N = 70 (%)pOR95% CIp
Demographics
 Sex, male184 (58.0)154 (62.3)46 (61.4)0.89
 Age ≥ 50 years275 (86.8)212 (85.8)63 (90.0)0.43
 Mean age (± SD), years65.4 ± 17.064.8 ± 16.867.2 ± 17.70.30
 Median hospital stay until Candida BSI (IQR), days16 (7–31)15 (6–29)20 (10–34)0.09 
Hospital ward
 General ward254 (80.1)201 (84.1)47 (67.1)0.0031.90.93–4.300.78
 Intensive care unit63 (19.9)38 (15.9)23 (32.9)    
Charlson comorbidity index3.4 ± 2.73.0 ± 2.44.6 ± 3.1< 0.0011.281.13–1.45< 0.001
Underlying condition
 Solid tumor114 (35.9)91 (36.8)23 (32.9)0.57
 Cardiovascular disease102 (32.2)72 (29.1)30 (42.9)0.04
 Diabetes mellitus90 (28.4)68 (27.5)22 (31.4)0.55
 Chronic lung disease51 (16.1)36 (14.6)15 (21.4)0.20
 Chronic kidney failure50 (15.8)36 (14.6)14 (20.0)0.27
 Chronic liver disease41 (12.9)26 (10.5)15 (21.4)0.02
 Solid organ transplantation27 (8.5)22 (8.9)5 (7.1)0.81
 Hematological malignancy20 (6.3)15 (6.1)5 (7.1)0.78
 Hematopoietic stem cell transplantation9 (2.8)6 (2.4)3 (4.3)0.41
Risk factors for candidemia
 Previous antibiotic therapy297 (93.6)232 (93.9)65 (92.9)0.78
 Central venous catheter225 (71.0)171 (69.2)54 (77.1)0.23
 TPN during candidemia158 (49.8)118 (47.8)40 (57.1)0.17
 Previous corticosteroid therapy72 (22.7)53 (21.5)19 (27.1)0.33
 Abdominal surgery85 (26.8)65 (26.3)20 (28.6)0.76
 Immunosuppressive therapy47 (14.8)39 (15.8)8 (11.4)0.45
 Neutropenia10 (3.2)7 (2.8)3 (4.3)0.46
Previous antifungal treatment49 (15.4)37 (15.0)12 (17.1)0.71
Source of infection
 Central venous catheter141 (44.5)122 (49.9)19 (27.1)0.0010.420.20–0.880.02
 Primary98 (30.9)71 (28.7)27 (38.6)0.14 
 Abdomen39 (12.3)22 (8.9)17 (24.3)0.0011.890.76–4.660.17
 Urinary tract23 (7.3)22 (8.9)1 (1.4)0.030.110.12–1.020.05-
 Infective endocarditis3 (0.9)3 (1.2)0 (0)1
 Other13 (4.1)7 (2.8)6 (8.6)0.05
Septic shock99 (31.2)65 (26.3)34 (48.6)0.0012.141.08–4.240.02
Initial adequate antifungal therapy130 (41.0)95 (38.5)35 (50.0)0.091.410.71–2.810.32
Adequate source control of the infection*124/288 (43.1)94/225 (41.8)30/63 (47.6)0.471.680.84–3.350.14
Hemodialysis after candidemia onset7 (2.2)2 (0.8)5 (7.1)0.0078.551.35–53.950.02
  1. *The source of the infection was susceptible of control in 288 patients
  2. BSI bloodstream infection, IQR interquartile range, SD standard deviation, TPN total parenteral nutrition