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Table 1 Comparison of the main demographic and clinical characteristics of study population

From: Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts

VariableAll episodes, N = 317 (%)Non-septic shock, N = 218 (%)Septic shock, N = 99 (%)p value
Demographics
 Sex, male184 (58.0)141 (64.7)43 (43.4)0.17
 Mean age (± SD), years65.4 ± 17.065.2 ± 18.666.9 ± 15.20.77
 Age ≥ 50 years275 (86.4)183 (83.9)92 (92.9)0.03
 Median hospital stay until Candida BSI (IQR), days16 (7–31)17 (6–32)14 (8–28)0.18
Hospital ward stay at the time of candidemia onset
 General ward254 (80.1)192 (88.1)62 (62.6)0.001
 Intensive care unit63 (19.9)26 (11.9)37 (37.4)
Charlson comorbidity index3.4 ± 2.73.4 ± 2.63.3 ± 2.80.71
Underlying condition
 Solid tumor114 (35.9)77 (35.3)37 (37.4)0.80
 Cardiovascular disease102 (32.2)69 (31.7)33 (33.3)0.79
 Diabetes mellitus90 (28.4)57 (26.1)33 (33.3)0.22
 Chronic Lung disease51 (16.1)35 (16.1)16 (16.2)1
 Chronic kidney failure50 (15.8)32 (14.7)18 (18.2)0.50
 Chronic liver disease41 (12.9)27 (12.4)14 (14.1)0.74
 Solid organ transplantation27 (8.5)19 (8.7)8 (8.1)1
 Hematological malignancy20 (6.3)16 (7.3)4 (4.0)0.32
 Hematopoietic stem cell transplantation9 (2.8)8 (3.7)1 (1.0)0.28
Risk factors for candidemia
 Previous antibiotic therapy297 (93.6)202 (92.7)95 (96.0)0.32
 Central venous catheter225 (71.0)150 (68.8)75 (75.8)0.23
 TPN during candidemia158 (49.8)101 (46.3)57 (57.6)0.07
 Previous corticosteroid therapy72 (22.7)51 (23.4)21 (22.1)0.77
 Abdominal surgery85 (26.8)52 (23.9)33 (33.3)0.10
 Immunosuppressive therapy47 (14.8)36 (16.5)11 (11.1)0.23
 Neutropenia10 (3.2)9 (4.1)1 (1.0)0.18
Previous antifungal treatment49 (15.4)37 (17.0)12 (12.1)0.32
Source of infection
 Central venous catheter141 (44.5)101 (46.3)40 (40.4)0.33
 Primary98 (30.9)73 (33.5)25 (25.3)0.15
 Abdomen39 (12.3)19 (8.7)20 (20.2)0.006
 Urinary tract23 (7.3)18 (8.3)5 (5.1)0.36
 Infective endocarditis3 (0.9)1 (0.5)2 (2.0)0.23
 Other13 (4.1)6 (2.8)7 (7.1)0.12
Candida species
C. albicans134 (42.3)91 (41.7)43 (43.4)0.80
C. glabrata58 (18.3)38 (17.4)20 (20.2)0.63
C. parapsilosis55 (17.4)40 (18.3)15 (15.2)0.52
C. tropicalis29 (9.1)22 (10.1)7 (7.1)0.52
C. krusei6 (1.9)4 (1.8)2 (2.0)1
C. lusitaniae4 (1.3)2 (0.9)2 (2.0)0.59
C. auris27 (8.5)18 (8.3)9 (9.1)0.86
 Other13 (4.1)11 (5.0)2 (2.0)0.35
Resistant strains
 Fluconazole45 (14.1)29 (13.3)16 (16.2)0.73
 Echinocandins3 (0.9)2 (0.9)1 (1.0)1
  1. BSI bloodstream infection, IQR interquartile range, SD standard deviation, TPN total parenteral nutrition