Variable | All episodes, N = 317 (%) | Non-septic shock, N = 218 (%) | Septic shock, N = 99 (%) | p value |
---|---|---|---|---|
Demographics | ||||
Sex, male | 184 (58.0) | 141 (64.7) | 43 (43.4) | 0.17 |
Mean age (± SD), years | 65.4 ± 17.0 | 65.2 ± 18.6 | 66.9 ± 15.2 | 0.77 |
Age ≥ 50 years | 275 (86.4) | 183 (83.9) | 92 (92.9) | 0.03 |
Median hospital stay until Candida BSI (IQR), days | 16 (7–31) | 17 (6–32) | 14 (8–28) | 0.18 |
Hospital ward stay at the time of candidemia onset | ||||
General ward | 254 (80.1) | 192 (88.1) | 62 (62.6) | 0.001 |
Intensive care unit | 63 (19.9) | 26 (11.9) | 37 (37.4) | |
Charlson comorbidity index | 3.4 ± 2.7 | 3.4 ± 2.6 | 3.3 ± 2.8 | 0.71 |
Underlying condition | ||||
Solid tumor | 114 (35.9) | 77 (35.3) | 37 (37.4) | 0.80 |
Cardiovascular disease | 102 (32.2) | 69 (31.7) | 33 (33.3) | 0.79 |
Diabetes mellitus | 90 (28.4) | 57 (26.1) | 33 (33.3) | 0.22 |
Chronic Lung disease | 51 (16.1) | 35 (16.1) | 16 (16.2) | 1 |
Chronic kidney failure | 50 (15.8) | 32 (14.7) | 18 (18.2) | 0.50 |
Chronic liver disease | 41 (12.9) | 27 (12.4) | 14 (14.1) | 0.74 |
Solid organ transplantation | 27 (8.5) | 19 (8.7) | 8 (8.1) | 1 |
Hematological malignancy | 20 (6.3) | 16 (7.3) | 4 (4.0) | 0.32 |
Hematopoietic stem cell transplantation | 9 (2.8) | 8 (3.7) | 1 (1.0) | 0.28 |
Risk factors for candidemia | ||||
Previous antibiotic therapy | 297 (93.6) | 202 (92.7) | 95 (96.0) | 0.32 |
Central venous catheter | 225 (71.0) | 150 (68.8) | 75 (75.8) | 0.23 |
TPN during candidemia | 158 (49.8) | 101 (46.3) | 57 (57.6) | 0.07 |
Previous corticosteroid therapy | 72 (22.7) | 51 (23.4) | 21 (22.1) | 0.77 |
Abdominal surgery | 85 (26.8) | 52 (23.9) | 33 (33.3) | 0.10 |
Immunosuppressive therapy | 47 (14.8) | 36 (16.5) | 11 (11.1) | 0.23 |
Neutropenia | 10 (3.2) | 9 (4.1) | 1 (1.0) | 0.18 |
Previous antifungal treatment | 49 (15.4) | 37 (17.0) | 12 (12.1) | 0.32 |
Source of infection | ||||
Central venous catheter | 141 (44.5) | 101 (46.3) | 40 (40.4) | 0.33 |
Primary | 98 (30.9) | 73 (33.5) | 25 (25.3) | 0.15 |
Abdomen | 39 (12.3) | 19 (8.7) | 20 (20.2) | 0.006 |
Urinary tract | 23 (7.3) | 18 (8.3) | 5 (5.1) | 0.36 |
Infective endocarditis | 3 (0.9) | 1 (0.5) | 2 (2.0) | 0.23 |
Other | 13 (4.1) | 6 (2.8) | 7 (7.1) | 0.12 |
Candida species | ||||
C. albicans | 134 (42.3) | 91 (41.7) | 43 (43.4) | 0.80 |
C. glabrata | 58 (18.3) | 38 (17.4) | 20 (20.2) | 0.63 |
C. parapsilosis | 55 (17.4) | 40 (18.3) | 15 (15.2) | 0.52 |
C. tropicalis | 29 (9.1) | 22 (10.1) | 7 (7.1) | 0.52 |
C. krusei | 6 (1.9) | 4 (1.8) | 2 (2.0) | 1 |
C. lusitaniae | 4 (1.3) | 2 (0.9) | 2 (2.0) | 0.59 |
C. auris | 27 (8.5) | 18 (8.3) | 9 (9.1) | 0.86 |
Other | 13 (4.1) | 11 (5.0) | 2 (2.0) | 0.35 |
Resistant strains | ||||
Fluconazole | 45 (14.1) | 29 (13.3) | 16 (16.2) | 0.73 |
Echinocandins | 3 (0.9) | 2 (0.9) | 1 (1.0) | 1 |