From: Dynamic LTR retrotransposon transcriptome landscape in septic shock patients
Variable | Normal HLA DR on day 3 (n = 10) | Low HLA DR on day 3 (n = 10) | Whole cohort (n = 20) | P value |
---|---|---|---|---|
Demographics | ||||
 Gender (male) | 8 (80) | 5 (50) | 13 (65) | 0.315 |
 Age (years) | 59 [54–67] | 57 [46–69] | 59 [52–68] | 0.665 |
Admission data | ||||
 SOFA Score day 1 | 8 [6–9] | 11 [9–16] | 9 [8–12] | 0.018 |
 SAPSII day 1 | 44 [33–45] | 58 [47–68] | 45 [34–56] | 0.052 |
Primary site of infection | Â | Â | Â | 0.912 |
 Pulmonary | 4 (20) | 4 (20) | 8 (40) |  |
 Abdominal | 3 (15) | 5 (25) | 8 (40) |  |
 Other | 3 (15) | 1 (5) | 4 (20) |  |
Type of primary infection | Â | Â | Â | 0.631 |
 Community acquired | 3 (15) | 6 (30) | 9 (45) |  |
 Hospital acquired | 6 (30) | 3 (15) | 9 (45) |  |
 Reanimation acquired | 1 (5) | 1 (5) | 2 (10) |  |
Type of detection | ||||
 Microbiologically documented infection | 0 (0) | 2 (10) | 2 (10) | 0.474 |
 Primary site of infection | 10 (50) | 8 (40) | 18 (90) | 0.474 |
Hydrocortisone | 5 (25) | 7 (35) | 12 (60) | 0.739 |
Monocyte HLA-DR expression | ||||
 % of mHLA-DR on day 1 | 63 [50–70] | 29 [20–42] | 45 [31–70] | 0.007 |
 % of mHLA-DR on day 3 | 63 [51–80] | 17 [12–25] | 36 [18–63] | < 0.001 |
Outcomes | ||||
 Secondary infection | 0 (0) | 2 (20) | 2 (10) | 0.796 |
 Hospital length of stay (days) | 38.5 [28–58] | 31 [14–42] | 34 [21–48] | 1.000 |
 ICU length of stay (days) | 5.5 [4–20] | 8 [5–10] | 6.5 [5–13] | 1.000 |
 Non-survivors at day 28 | 2 (20) | 7 (70) | 9 (45) | 0.052 |