Skip to main content

Table 1 Patient characteristics of the IMMUNOSEPSIS cohort subset according to the mHLA-DR expression on day 3 (descriptive and discovery phase)

From: Dynamic LTR retrotransposon transcriptome landscape in septic shock patients

Variable

Normal HLA DR on day 3 (n = 10)

Low HLA DR on day 3 (n = 10)

Whole cohort (n = 20)

P value

Demographics

 Gender (male)

8 (80)

5 (50)

13 (65)

0.315

 Age (years)

59 [54–67]

57 [46–69]

59 [52–68]

0.665

Admission data

 SOFA Score day 1

8 [6–9]

11 [9–16]

9 [8–12]

0.018

 SAPSII day 1

44 [33–45]

58 [47–68]

45 [34–56]

0.052

Primary site of infection

   

0.912

 Pulmonary

4 (20)

4 (20)

8 (40)

 

 Abdominal

3 (15)

5 (25)

8 (40)

 

 Other

3 (15)

1 (5)

4 (20)

 

Type of primary infection

   

0.631

 Community acquired

3 (15)

6 (30)

9 (45)

 

 Hospital acquired

6 (30)

3 (15)

9 (45)

 

 Reanimation acquired

1 (5)

1 (5)

2 (10)

 

Type of detection

 Microbiologically documented infection

0 (0)

2 (10)

2 (10)

0.474

 Primary site of infection

10 (50)

8 (40)

18 (90)

0.474

Hydrocortisone

5 (25)

7 (35)

12 (60)

0.739

Monocyte HLA-DR expression

 % of mHLA-DR on day 1

63 [50–70]

29 [20–42]

45 [31–70]

0.007

 % of mHLA-DR on day 3

63 [51–80]

17 [12–25]

36 [18–63]

< 0.001

Outcomes

 Secondary infection

0 (0)

2 (20)

2 (10)

0.796

 Hospital length of stay (days)

38.5 [28–58]

31 [14–42]

34 [21–48]

1.000

 ICU length of stay (days)

5.5 [4–20]

8 [5–10]

6.5 [5–13]

1.000

 Non-survivors at day 28

2 (20)

7 (70)

9 (45)

0.052

  1. Categorical variables are expressed as n(%) and continuous variables as median [Q1–Q3]. Comparisons between normal and low mHLA-DR expression groups, at day 3, were performed with a Chi-squared test for qualitative variables and Mann-Whitney test for quantitative variables, as appropriate. Values in bold indicate significance at p < 0.05. ICU intensive care unit, SOFA sequential organ failure assessment, SAPS Simplified Acute Physiology Score