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Fig. 2 | Critical Care

Fig. 2

From: Dynamic LTR retrotransposon transcriptome landscape in septic shock patients

Fig. 2

HERV/MaLR transcriptome landscape in the whole blood (descriptive phase). a Percentages and absolute counts (number presented inside the bars) of expressed loci (probeset intensity above threshold), within individual groups of “HERV_prototypes,” “HERV_Dfam,” and “MaLR_Dfam” repertoires. “HERV_prototypes” were grouped by classes of retroviruses, namely gamma-retrovirus (green), beta-retrovirus (pink), and spuma-epsilon like retrovirus (blue). “HERV and MaLR Dfam” repertoires are depicted as a global homogeneous entity (purple). b Volcano plots derived from the HERV/MaLR differential expression analysis, between septic shock patients and HV on day 1 (left) or day 3 (right). The x-axis represents the log2 fold change values and the y-axis represents the -log10 adjusted P values. Each point represents a given probeset. Statistically and biologically significant probesets (adjusted P value < 0.05, │log2FC│ > 1) are colored (red = downregulated, green = upregulated). c Venn diagrams from the HERV/MaLR differential expression analyses, according to the day of sampling and mHLA-DR expression (compared to HV). Upregulated probesets are in green and downregulated probesets are in red

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