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Table 1 Description of the 34 asplenic or hyposplenic patients with pneumococcal purpura fulminans

From: Pneumococcal purpura fulminans in asplenic or hyposplenic patients: a French multicenter exposed-unexposed retrospective cohort study

 

Hyposplenic or asplenic patients, N = 34

Asplenia

29/34 (85%)

Hyposplenia

5/34 (15%)

Cause of asplenia

 Congenital

3/29 (10%)

 Post-splenectomy

26/29 (90%)

  Trauma

11/26 (42%)

  Immune thrombocytopenic purpura

6/26 (23%)

  Pancreatic cancer

3/26 (12%)

  Left diaphragmatic hernia

1/26 (4%)

  Lymphoma

1/26 (4%)

  Myelodysplasia

1/26 (4%)

  Benign splenomegaly

1/26 (4%)

  Unknown

1/26 (4%)

Cause of hyposplenia

 Splenic irradiation

5/5 (100%)

 Sickle cell disease

0/5 (0%)

Time interval between asplenia/hyposplenia and ICU admission, and pneumococcal vaccination coverage

 Time interval between asplenia/hyposplenia and ICU admission (years)

20 [9–32]

 Time interval between asplenia/hyposplenia and ICU admission ≤ 2 years

2/34 (6%)

 Time interval between asplenia/hyposplenia and ICU admission (years)*

19 [9–30]

 Time interval between asplenia/hyposplenia and ICU admission ≤ 2 years*

2/31 (6%)

 Long-term antibiotic prophylaxis

1/32 (3%)

 Pneumococcal vaccination

11/31 (35%)

  1. *After exclusion of the three patients with congenital asplenia