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Table 1 Baseline characteristics of the included trials

From: Validation of neuromuscular blocking agent use in acute respiratory distress syndrome: a meta-analysis of randomized trials

StudyPatients no. (sites)Target patientsNMBA groupControl groupVentilation strategySedation target
Gainnier et al. [28]56 (4)AECC criteria for ARDS with PaO2/FiO2 ratio < 150 at a PEEP ≥ 5 cm H2O within 36 hOne bolus of 50 mg of cisatracurium infusion, followed by a continuous infusion at an initial rate of 5 μg/kg per min for 48 hAn infusion of saline at a rate of 4 mL/hAssist-control mode for at least 48 h. Tidal volume 6–8 mL/kg of ideal body weightMidazolam and sufentanil to obtain a Ramsay score of 6
Forel et al. [29]36 (3)AECC criteria for ARDS with PaO2/FiO2 ratio < 200 mmHg at a PEEP ≥ 5 cm H2O within 48 h of onsetOne bolus of 50 mg of cisatracurium infusion, followed by a continuous infusion at an initial rate of 5 μg/kg per min for 48 hAn infusion of saline at a rate of 4 mL/hAssist/control-volume with a tidal volume of 4–8 mL/kg predicted body weight and a plateau pressure of ≤ 30 cm H2OMidazolam (3–30 mg/h) and sufentanil (10–150 μg/h) to obtain a Ramsay score of 6
Papazian et al. [10]339 (12)AECC criteria for ARDS with PaO2/FiO2 ratio < 150 mmHg at a PEEP ≥ 5 cm H2O within 48 hOne bolus infusion of 15 mg of cisatracurium, followed by a continuous infusion of 37.5 mg per hour for 48 hAn infusion of saline at the same rate as NMBA groupVolume assist-control mode, with a tidal volume of 6 to 8 mL per kilogram of predicted body weightObtain a Ramsay score of 6
Lyu et al. [30]96 (1)Moderate to severe ARDS with a PaO2/FiO2 less than 150 with PEEP at least 5 within the first 48 hOne bolus infusion of 0.1 mg/kg vecuronium, followed by a continuous infusion of 0.05 mg/kg per hour for 24 to 48 hUsual careVolume control mode, with a tidal volume of 4 to 8 mL per kilogram of predicted body weightSedation of midazolam and sufentanil
Rao et al. [32]41 (1)Berlin criteria for moderate-to-severe ARDSContinuous infusion of 1 μg/kg per min of vecuroniumUsual careProtective ventilation strategy, with a tidal volume of 6 mL per kilogram of ideal predicted body weight, with a plateau pressure ≤ 30 cm H2OMidazolam and sufentanil or midazolam and fentanyl with a Ramsay score of 2 to 4
Guervilly et al. [31]24 (2)Moderate to severe ARDS with a PaO2/FiO2 less than 150 with PEEP at least 5 within the first 48 hCisatracurium besylate was given using a 3-mL rapid intravenous infusion of 15 mg followed by a continuous infusion of 37.5 mg/hUsual careVolume-assist control mode with a tidal volume of 6 mL/kg/IPBW (ideal predicted body weight)Midazolam and sufentanil to achieve a Ramsay score of 6
Moss et al. [21]1006 (48)present for less than 48 h: PaO2:FiO2 of less than 150 mmHg with a PEEP of 8 cm or more of waterAn intravenous bolus of 15 mg of cisatracurium, followed by a continuous infusion of 37.5 mg per hour for 48 hAn infusion of saline at the same rate as NMBA groupProtective ventilation strategy, with a tidal volume of 6 mL per kilogram of ideal predicted body weight, with a PEEP ≥ 8 cmH2OA RASS score of 0 or − 1 in the control group